Effects of early-in-life bladder stimulation on adults
生命早期膀胱刺激对成年人的影响
基本信息
- 批准号:6803408
- 负责人:
- 金额:$ 14.5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2003
- 资助国家:美国
- 起止时间:2003-09-30 至 2006-07-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (provided by applicant): Pain originating from the urinary bladder is a common clinical entity affecting more than 50% of females at some time in their lives. Some conditions are easy to treat, but others, such as interstitial cystitis (IC) have proven resistant to diagnosis and treatment. There are multiple proposed etiologies for IC with the common theme of an eventual sensitization/activation of sensory elements: abnormalities in the periphery lead to central neurophysiological changes that become expressed as enhanced sensory (pain-urgency) and reflex responses (i.e. reduced bladder capacity) which may outlast "triggering" events within the bladder. In somatic systems, it has been demonstrated that exposure to painful stimuli during early life can produce permanent changes in the neuroanatomical and neurophysiological substrates that process nociceptive information. Since 10-28% of adult patients with IC report urinary bladder symptoms as children a logical avenue for exploration is an examination of the effects of early-in-life painful bladder experiences on bladder responses in adults since individuals who are "primed" for hypersensitivity of the bladder could have pain that is both easily triggered and manifested as a sustained response to normally self-limited events. The hypothesis central to these studies is:
A peripheral and spinal neuronal sensitization process initiated by early-in-life, high-intensity primary afferent activation, can enhance susceptibility to pathological urinary bladder pain as an adult. This early-in-life process leads to a hypersensitive state that is manifested by lowered intravesical stimulus thresholds needed for pain evocation and augmented responses to supra-threshold stimuli.
To test this hypothesis reflex, primary afferent neuronal and spinal neuronal responses to urinary bladder distension (UBD) will be characterized in rats, which are given high-intensity UBD and/or inflammatory stimuli (intravesical zymosan) in the neonatal, pre-pubescent or post-pubescent periods. These exploratory studies will lay the groundwork for potential, novel therapeutic modalities for the treatment of urinary bladder pain by identifying substrates of hypersensitivity development and thereby treatment of urinary bladder pain by identifying substrates of hypersensitivity development and thereby presenting targets for intervention. Translation to the treatment of IC would be highly probable.
描述(由申请人提供):膀胱疼痛是一种常见的临床症状,超过50%的女性在一生中的某个时候都会受到影响。有些疾病很容易治疗,但其他疾病,如间质性膀胱炎(IC)已被证明难以诊断和治疗。IC的病因有多种,其共同的主题是最终敏化/激活感觉元素:外周异常导致中枢神经生理变化,表现为感觉(疼痛-急迫性)和反射反应(即膀胱容量减少)的增强,这些变化可能比膀胱内的“触发”事件持续时间更长。在躯体系统中,已经证明在生命早期暴露于疼痛刺激可以产生处理伤害性信息的神经解剖和神经生理基质的永久性变化。由于10-28%的成年IC患者报告了儿童时期的膀胱症状,因此探索早期膀胱疼痛经历对成人膀胱反应的影响是合乎逻辑的途径,因为膀胱过敏的个体可能会有疼痛,这种疼痛既容易触发,又表现为对通常自限性事件的持续反应。这些研究的核心假设是:
项目成果
期刊论文数量(0)
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会议论文数量(0)
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ALAN RANDICH其他文献
ALAN RANDICH的其他文献
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{{ truncateString('ALAN RANDICH', 18)}}的其他基金
Neonatal Bladder Inflammation, Opioids, and Adult Bladder Pain
新生儿膀胱炎症、阿片类药物和成人膀胱疼痛
- 批准号:
8011777 - 财政年份:2010
- 资助金额:
$ 14.5万 - 项目类别:
Neonatal Bladder Inflammation, Opioids, and Adult Bladder Pain
新生儿膀胱炎症、阿片类药物和成人膀胱疼痛
- 批准号:
7795829 - 财政年份:2008
- 资助金额:
$ 14.5万 - 项目类别:
Neonatal Bladder Inflammation, Opioids, and Adult Bladder Pain
新生儿膀胱炎症、阿片类药物和成人膀胱疼痛
- 批准号:
7596435 - 财政年份:2008
- 资助金额:
$ 14.5万 - 项目类别:
Early-In-Life Inflammation Effects on Urinary Bladder Sensation
生命早期炎症对膀胱感觉的影响
- 批准号:
7417783 - 财政年份:2007
- 资助金额:
$ 14.5万 - 项目类别:
Early-In-Life Inflammation Effects on Urinary Bladder Sensation
生命早期炎症对膀胱感觉的影响
- 批准号:
7255103 - 财政年份:2007
- 资助金额:
$ 14.5万 - 项目类别:
Early-In-Life Inflammation Effects on Urinary Bladder Sensation
生命早期炎症对膀胱感觉的影响
- 批准号:
7624351 - 财政年份:2007
- 资助金额:
$ 14.5万 - 项目类别:
Effects of early-in-life bladder stimulation on adults
生命早期膀胱刺激对成年人的影响
- 批准号:
6710389 - 财政年份:2003
- 资助金额:
$ 14.5万 - 项目类别: