PERIPHERAL & CENTRAL SUBSTRATES OF PRIMARY HYPERALGESIA
周边设备
基本信息
- 批准号:2393968
- 负责人:
- 金额:$ 12.28万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1997
- 资助国家:美国
- 起止时间:1997-07-01 至 2001-04-30
- 项目状态:已结题
- 来源:
- 关键词:afferent nerve dorsal horn electrophysiology evoked potentials excitatory aminoacid glutamate receptor heat stimulus hyperalgesia inflammation inhibitor /antagonist laboratory rat mechanical pressure mechanoreceptors neuropharmacology neurophysiology peripheral nervous system receptor expression single cell analysis stimulus /response thermoreception thermoreceptors zymosan
项目摘要
DESCRIPTION (Adapted from the Investigator's Abstract): Tissue damage and
nerve injury are often associated with inflammation. The common signs of
inflammation include hyperalgesia, redness, swelling, and increased
temperature. The overall goal of our research program is to determine the
mechanisms responsible for the development and maintenance of primary
hyperalgesia. The specific goals of this proposal are to (1) identify which
peripheral afferents contribute to zymosan-induced mechanical and thermal
hyperalgesia using single fiber recordings of low threshold mechanoreceptors
(LTMs), high threshold mechanoreceptors (HTMs), A-mechanoheat nociceptors
(AMHs), C-polymodal nociceptors (CPMs), and C-mechanonociceptors (CMNs), (2)
determine how mechanical and thermal stimulus-response functions (SRFs) of
nociceptive specific (NS) and wide dynamic range (WDR) spinal dorsal horn
neurons are affected under conditions of zymosan-induced inflammation, (3)
determine whether spinal administration of selective glutamate receptor
antagonists differentially affect the altered stimulus-response
characteristics of NS and WDR neurons to thermal and mechanical stimuli
under conditions of zymosan-induced inflammation, and (4) determine whether
zymosan-induced inflammation results in hyperexcitability of NS and WDR
spinal dorsal horn neurons and if so, whether it can be sustained in the
presence of glutamate receptor antagonists that block primary hyperalgesia
to thermal and mechanical stimuli.
These goals will be accomplished in electrophysiological and pharmacological
studies of primary hyperalgesia in the rat. Intraplantar administration of
the inflammatory agent zymosan will be used to produce primary hyperalgesia
to thermal and mechanical stimuli. In each aim, complete SRFs to thermal
(36 C - 50 C in 2 C increments) and mechanical stimuli (0.02 - 190 g) will
be generated before and at hourly intervals following administration of
zymosan. All units will be studied using a repeated measures design. These
studies will advance our understanding of the mechanisms of thermal and
mechanical primary hyperalgesia resulting from inflammation. Data obtained
from the pharmacological studies will help resolve some of the current
controversy over whether similar or different excitatory amino acids (EAAs)
mediate the production and/or maintenance of mechanical and thermal
hyperalgesia.
描述(改编自研究者摘要):组织损伤和
神经损伤通常与炎症有关。 的共同迹象
炎症包括痛觉过敏、发红、肿胀和增加
温度 我们研究计划的总体目标是确定
负责发展和维持初级教育的机构
痛觉过敏 本提案的具体目标是:(1)确定
外周传入有助于酵母多糖诱导的机械和热
使用低阈值机械感受器的单纤维记录的痛觉过敏
(LTM)、高阈值机械感受器(HTM)、A-机械热伤害感受器
(AMH)、C-多模态伤害感受器(CPM)和C-机械伤害感受器(CMN),(2)
确定机械和热刺激-响应函数(SRF)
伤害性特异性(NS)和宽动态范围(WDR)脊髓背角
神经元在酵母多糖诱导的炎症条件下受到影响,(3)
确定选择性谷氨酸受体的脊髓给药
拮抗剂不同地影响改变的刺激反应
NS和WDR神经元对热刺激和机械刺激的特性
在酵母聚糖诱导的炎症的条件下,和(4)确定是否
酵母多糖诱导的炎症导致NS和WDR的过度兴奋
脊髓背角神经元,如果是这样,它是否可以持续在
存在阻断原发性痛觉过敏的谷氨酸受体拮抗剂
热刺激和机械刺激。
这些目标将在电生理学和药理学方面得以实现
大鼠原发性痛觉过敏的研究。 足底给药
炎症剂酵母聚糖将用于产生原发性痛觉过敏
热刺激和机械刺激。 在每个目标中,完成SRF到热
(36 C - 50 C,增量为2 C)和机械刺激(0.02 - 190 g)将
在给药前和给药后每小时产生
酵母聚糖 将使用重复测量设计研究所有单元。 这些
研究将促进我们对热机制的理解,
由炎症引起的机械性原发性痛觉过敏。 获得的数据
将有助于解决目前的一些问题,
关于是否相似或不同的兴奋性氨基酸(EAA)的争议
介导机械和热的产生和/或维持
痛觉过敏
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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ALAN RANDICH其他文献
ALAN RANDICH的其他文献
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{{ truncateString('ALAN RANDICH', 18)}}的其他基金
Neonatal Bladder Inflammation, Opioids, and Adult Bladder Pain
新生儿膀胱炎症、阿片类药物和成人膀胱疼痛
- 批准号:
8011777 - 财政年份:2010
- 资助金额:
$ 12.28万 - 项目类别:
Neonatal Bladder Inflammation, Opioids, and Adult Bladder Pain
新生儿膀胱炎症、阿片类药物和成人膀胱疼痛
- 批准号:
7795829 - 财政年份:2008
- 资助金额:
$ 12.28万 - 项目类别:
Neonatal Bladder Inflammation, Opioids, and Adult Bladder Pain
新生儿膀胱炎症、阿片类药物和成人膀胱疼痛
- 批准号:
7596435 - 财政年份:2008
- 资助金额:
$ 12.28万 - 项目类别:
Early-In-Life Inflammation Effects on Urinary Bladder Sensation
生命早期炎症对膀胱感觉的影响
- 批准号:
7417783 - 财政年份:2007
- 资助金额:
$ 12.28万 - 项目类别:
Early-In-Life Inflammation Effects on Urinary Bladder Sensation
生命早期炎症对膀胱感觉的影响
- 批准号:
7255103 - 财政年份:2007
- 资助金额:
$ 12.28万 - 项目类别:
Early-In-Life Inflammation Effects on Urinary Bladder Sensation
生命早期炎症对膀胱感觉的影响
- 批准号:
7624351 - 财政年份:2007
- 资助金额:
$ 12.28万 - 项目类别:
Effects of early-in-life bladder stimulation on adults
生命早期膀胱刺激对成年人的影响
- 批准号:
6710389 - 财政年份:2003
- 资助金额:
$ 12.28万 - 项目类别:
Effects of early-in-life bladder stimulation on adults
生命早期膀胱刺激对成年人的影响
- 批准号:
6803408 - 财政年份:2003
- 资助金额:
$ 12.28万 - 项目类别:
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