Sensory Testing in Subjects with Interstitial Cystitis

间质性膀胱炎受试者的感官测试

• 批准号: 6802842
• 负责人: MARY P FITZGERALD
• 金额: $ 7.1万
• 依托单位: LOYOLA UNIVERSITY CHICAGO
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-20 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6802842
• 关键词: clinical research; diagnosis design /evaluation; electrodes; human subject; hyperalgesia; interstitial cystitis; noninvasive diagnosis; pain threshold; patient oriented research; sensory disorder diagnosis; sensory feedback; urinary bladder epithelium; urinary electronic stimulator; urinary tract disorder diagnosis; urinary tract motility /pressure

DESCRIPTION (provided by applicant): Recent insights into the neurobiology of interstitial cystitis (IC) and into mechanisms of visceral pain suggest that, like other visceral pain syndromes, IC may be associated with hyperalgesia of the bladder itself, and central sensitization of pain pathways from the bladder. There also may be increased sensitivity to stimulation of body wall tissues in dermatomes to which bladder pain refers. Advances in our understanding of bladder hyperalgesia to distension and the presence of such altered cutaneous stimulation thresholds will help us to design more elegant and evidence-based treatments for IC. This proposal first describes a simple study to measure sensory aspects of bladder sensation with filling in subjects with IC and in controls. Secondly, the use of a Neurometer as a simple instrument to measure cutaneous thresholds to stimulation at frequencies of 2000Hz, 250 Hz, and 5 Hz is described. Finally, testing for the presence of temporal summation of pain and bladder filling sensations as a measure of centralized sensitization of pain pathways is described. If the results of this psychophysical testing prove to be significantly altered in subjects with IC, simple clinical testing of pelvic referral dermatomes may allow clinicians to assess patients for central sensitization, then design and evaluate treatments accordingly.

描述（由申请人提供）：最近对间质性膀胱炎（IC）的神经生物学和内脏痛机制的了解表明，与其他内脏痛综合征一样，IC可能与膀胱本身的痛觉过敏和来自膀胱的疼痛通路的中枢致敏有关。也可能存在对膀胱疼痛所指的皮区中的体壁组织的刺激的敏感性增加。我们对膀胱扩张痛敏的理解的进展以及这种改变的皮肤刺激阈值的存在将帮助我们设计更优雅且基于证据的IC治疗方法。该提案首先描述了一个简单的研究，以测量膀胱感觉的感觉方面与IC和对照组的主题填充。其次，描述了使用神经测量仪作为测量皮肤对2000 Hz、250 Hz和5 Hz频率刺激的阈值的简单仪器。最后，描述了测试疼痛和膀胱充盈感觉的时间总和的存在，作为疼痛途径集中致敏的测量。如果这种心理物理测试的结果被证明是显着改变与IC的主题，简单的临床测试盆腔转诊皮节可以让临床医生评估患者的中枢致敏，然后设计和评估相应的治疗。