BOTULINUM TOXIN THERAPY FOR INTERSTITIAL CYSTITIS/CHRON*

描述（由申请人提供）： 洛约拉女性盆腔医学团队建议参加间质性膀胱炎/慢性盆腔疼痛（IC/CPP）临床试验网络，以促进对患有这些复杂疾病的女性的临床护理的理解。我们的多学科团队具有临床规模和经证实的能力，可以参与合作研究的开发，并招募最终批准的方案。作为芝加哥地区的IC/CPP转介中心，我们相信我们的参与将为该集团带来庞大的患者基础和长期的临床经验，从而使该网络受益，并将通过为患者提供最先进的治疗而使患者受益。 根据RFA的要求，我们提供了一个概念方案，研究将肉毒杆菌毒素注射到逼尿肌或骨盆底肌肉组织中治疗IC/CPP。 Loyola团队： 理解这一重要治疗网络的重要性， 可以招募和留住种族，经济和民族多样性的患者， 有经验丰富的调查人员，包括医生，护士，物理治疗师和尿动力学技术人员， 目前的临床实践为IC/CPP提供手术、药理学和行为治疗， 能够保证数据的管理和传输， 期待与其他治疗中心合作，以最大限度地提高我们患者的治疗网络效益。

DESCRIPTION (provided by applicant): The Loyola Female Pelvic Medicine team proposes to participate in the Interstitial Cystitis/Chronic Pelvic Pain (IC/CPP) Clinical Trials Network in order to advance the understanding of the clinical care of women with these complex disorders. Our multidisciplinary team has the clinical volume and proven ability to participate in development of cooperative studies and to recruit to finally approved protocols. As a referral center for IC/CPP in the Chicago area, we believe our participation will benefit the network by bringing a large patient base and a long clinical experience to the group, and will benefit our patients by making state-of-the-art treatments available to them. As requested in the RFA, we offer a concept protocol which studies the use of botulinum toxin injection into either detrusor or pelvic floor musculature, for the treatment of IC/CPP. The Loyola team: Understands the significance of this important treatment network, Can recruit and retain patients of racial, economic and ethnic diversity, Has experienced investigators including physicians, nurses, physical therapist and urodynamic technicians, Has a current clinical practice which offers surgical, pharmacological and behavioral treatment for IC/CPP, Can ensure data management and transmission, and Looks forward to cooperation with the other treatment centers in order to maximize the benefits of this treatment network for our patients.