Nocturia and Chronic Medical illness

夜尿症和慢性疾病

• 批准号: 7591265
• 负责人: MARY P FITZGERALD
• 金额: $ 15.2万
• 依托单位: LOYOLA UNIVERSITY CHICAGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7591265
• 关键词: Affect; Algorithms; Award; Biometry; Chronic; Clinic; Clinical; Clinical Research; Consult; Continuing Education; Data; Development; Diabetes Mellitus; Education; Epidemiology; Evaluation; Excretory function; Future; Glycosylated hemoglobin A; Health; Health Personnel; Intake; Investigation; Kidney; Kidney Concentrating Ability; Kidney Diseases; Knowledge; Life; Liquid substance; Measures; Medical; Medical center; Medicine; Mentors; Mid-Career Clinical Scientist Award (K24); Mining; Modeling; Nocturia; Non-Insulin-Dependent Diabetes Mellitus; Osmolalities; Output; Patients; Pharmaceutical Preparations; Prevalence; Quality of life; Renal function; Research; Research Personnel; Research Project Grants; Severities; Sodium; Symptoms; Time; Urine; Wages; Water; career; glycemic control; interest; lower urinary tract symptoms; patient oriented research; urinary

DESCRIPTION (provided by applicant): This application outlines plans to further my personal education and mentoring of junior clinical researchers through support from a Mid-Career Award in Patient Oriented Research. A new direction in clinical research is also described, with specific emphasis on the interaction of diabetes with nocturia and other lower urinary tract symptoms (LUTS). Although not in itself life-threatening, nocturia can severely adversely affect patient quality of life and can be an indicator of poor overall health. Several lines of evidence suggest that chronic medical illnesses and medications used to treat those illnesses may affect the prevalence and severity of those nocturia and other LUTS. Healthcare providers attempting to relieve nocturia/LUTS are faced with a major knowledge gap related to the investigation and treatment of nocturia/LUTS in the setting of medical illness, as the magnitude of the effect of each illness and combined illnesses on those LUTS is unknown. This proposal seeks to formally study the relationship between glycemic control, renal function and LUTS in patients with and without diabetes. The results of this original research and informative epidemiological data will then be integrated to begin to form a model of the interaction of several chronic medical illnesses with nocturia/LUTS, and development of algorithms for the evaluation and treatment of patients with nocturia in that setting. The projects described will also be hypothesis-generating and will serve as vehicles for mentoring of current and future Fellows and Residents who choose to become interested in this line of research. The protected time afforded by the K24 award will also allow my continuing education in biostatistics, and my participation in the mentoring activities of the biostatistical consulting team. Further education in renal medicine in line with my proposed research project will also be feasible, with attendance at didactic sessions within the Mines VA medical center. Finally, salary support will allow me to continue and expand my mentoring efforts for the benefit of current and future colleagues, fellows and residents.

描述（由申请人提供）： 该申请概述了通过以患者为导向的研究中职业生涯奖的支持，进一步促进我的个人教育和对初级临床研究人员的指导的计划。还描述了临床研究的新方向，特别强调糖尿病与夜尿和其他下尿路症状 (LUTS) 的相互作用。虽然夜尿症本身并不危及生命，但它会严重影响患者的生活质量，并且可能是整体健康状况不佳的一个指标。多项证据表明，慢性疾病和用于治疗这些疾病的药物可能会影响夜尿症和其他 LUTS 的患病率和严重程度。试图缓解夜尿症/LUTS 的医疗保健提供者面临着与医疗疾病背景下夜尿症/LUTS 的调查和治疗相关的重大知识差距，因为每种疾病和组合疾病对这些 LUTS 的影响程度尚不清楚。该提案旨在正式研究糖尿病患者和非糖尿病患者的血糖控制、肾功能和 LUTS 之间的关系。然后，将整合这项原始研究的结果和信息丰富的流行病学数据，开始形成几种慢性疾病与夜尿症/下尿路症状相互作用的模型，并开发用于评估和治疗该情况下夜尿症患者的算法。所描述的项目也将产生假设，并将作为指导当前和未来选择对这一研究领域感兴趣的研究员和住院医师的工具。 K24 奖项提供的受保护时间还允许我继续接受生物统计学教育，并参与生物统计咨询团队的指导活动。根据我提议的研究项目进行肾脏医学的进一步教育也是可行的，可以参加 Mines VA 医疗中心的教学课程。 最后，薪资支持将使我能够继续并扩大我的指导工作，以造福当前和未来的同事、研究员和住院医师。