"Palladium Catalysed Annulation Reactions of Functionalised Conjunctive Reagents"

“功能化联合试剂的钯催化成环反应”

• 批准号: 2293532
• 金额: --
• 依托单位: University of Sheffield
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2293532
• 关键词: Palladium; Catalysed; Annulation; Reactions; Functionalised

The manufacture of the opioid receptor antagonist Naloxone results in the formation of small concentrations of degradation products. In order to understand the degradation process, these degradants need to be characterised. This project aims to use chemical synthesis to access synthetic degradants, so that their structure can be confirmed and their mechanism of formation can be better understood

制造阿片受体拮抗剂纳洛酮会导致形成小浓度的降解产物。为了了解降解过程，需要对这些降解剂进行表征。本项目旨在通过化学合成获得合成降解物，从而确定其结构，更好地了解其形成机理。