Core--Statistical Facility

统计/计算核心是圣安东尼奥STI TM CRC提案不可或缺的组成部分，为所有体格检查、临床问卷、行为问卷和实验室测定以及所有研究临床活动（包括受试者/二分体跟踪和向卫生部门报告所需）提供数据收集和组织基础。统计/计算核心的成员将通过监督数据收集和确保STI TM CRC各组成部分的适当联系，确保研究项目的持续完整性。这些任务将通过使用由核心人员开发和维护的定制多功能数据库来完成。此外，统计/计算核心将提供计算机硬件和软件方面的专门知识，包括维护和升级STI TM CRC内的所有计算机系统。最后，在收集数据后，具有流行病学研究设计、统计分析技术和计算机编程专业知识的统计/计算核心成员将为包括STI TM CRC在内的研究项目开展的所有数据分析和解释活动提供中央支持系统，并将实施适当的分析 协作解决所有涉及统计数据分析的项目目标的方法。统计/计算核心的成员将与每个项目紧密结合，提供样本跟踪和识别，以及患者和二人组内样本的时间关联。行为项目每次访视时收集的数据将与微生物学研究项目和临床项目获得的结果相关联，以便将实验室结果与受试者的并发临床、行为、情境和其他特征相关联。特别是对于行为项目，统计/计算核心人员将全面参与数据分析的每一步，包括评估干预措施的影响、制定复杂的变量结构以及审查与了解和预防性传播感染有关的许多研究问题。

The Statistical/Computing Core is an indispensable component of the San Antonio STI TM CRC proposal, providing the data collection and organizational backbone for all physical examinations, clinical questionnaires, behavioral questionnaires, and laboratory assays, as well as all study clinic activities, including subject/dyad tracking and required reporting to health departments. Members of the Statistics/Computing Core will ensure the continued integrity of the Research Projects by overseeing data collection and ensuring the proper linkage of the various components of the STI TM CRC. These tasks will be accomplished through the use of a customized multi-functional database developed and maintained by Core personnel. In addition, the Statistical/Computing Core will provide expertise in computer hardware and software, including maintaining and upgrading all computer systems encompassed within the STI TM CRC. Finally, after data have been collected, members of the Statistical/Computing Core, with expertise in epidemiologic study design, statistical analysis techniques, and computer programming, will provide a central support system for all data analysis and interpretation activities undertaken by the Research Projects comprising the STI TM CRC, and will implement appropriate analytic methods for collaboratively addressing all Project Aims that involve statistical data analysis. Members of the Statistical/Computing Core will be closely integrated with each Project, providing specimen tracking and identification, as well as linkage of specimens across time within patients and dyads. Data collected at each visit for the Behavioral Project will be linked to results obtained from the Microbiology Research Projects and the Clinical Project in order to correlate laboratory findings with concurrent clinical, behavioral, situational, and other characteristics of the subjects. For the Behavioral Project in particular, Statistical/Computing Core personnel will be integrally involved at every step of the data analysis, including the assessment of intervention impact, the development of complex variable constructs, and the examination of numerous research questions relating to the understanding and prevention of STI transmission.