Core--Statistical Facility

核心——统计设施

• 批准号: 7477929
• 负责人: SONDRA PERDUE
• 金额: $ 25.17万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7477929
• 关键词: Acute; Address; Aerobic; Antibiotic Therapy; Antibiotics; Antibodies; Azithromycin; Bacterial Vaginosis; Behavioral; Biological Assay; Blood specimen; Candida; Caring; Cervical; Characteristics; Chlamydia; Chronic; Clinic Activity; Clinical; Collaborations; Complex; Computer Hardware; Computer Systems; Computer software; Cystitis; DNA Amplification Technics; Data; Data Analyses; Data Collection; Databases; Detection; Development; Diagnosis; Disease; Emerging Technologies; Endometrial; Endometritis; Endometrium; Enrollment; Ensure; Epidemiologic Studies; Evaluation; Female; Fluorescent Antibody Technique; Genital system; Genitourinary System Infection; Genitourinary system; Gonorrhea; Health; Histology; Human Resources; Infection; Inflammatory; Inflammatory Response; Intervention; Laboratories; Laboratory Finding; Link; Local Microbicides; Methods; Microbiology; Mycoplasma; Mycoplasma genitalium; Organism; Outcome Measure; Participant; Patients; Physical Examination; Piper; Polymerase Chain Reaction; Population; Prevention; Progress Reports; Questionnaires; Reporting; Research; Research Design; Research Project Grants; Resources; Risk; Role; Saliva; Sensitivity and Specificity; Sexually Transmitted Diseases; Specimen; Staining method; Stains; Standards of Weights and Measures; Statistical Computing; Statistical Data Interpretation; Study Subject; Support System; Symptoms; Syphilis; Techniques; Testing; Time; Tissue Sample; Tissues; Transport Process; Trichomonas; Triiodothyronine; Universities; Urinalysis; Urine; Vaccines; Vagina; Variant; Vertebral column; Visit; Washington; Woman; Work; base; clinical Diagnosis; computer program; desire; expectation; follow-up; genetic linkage analysis; improved; male; member; men; microbicide; pathogen; research clinical testing; response; sample collection; sample fixation; statistics; tool; transmission process; urinary

The Statistical/Computing Core is an indispensable component of the San Antonio STI TM CRC proposal, providing the data collection and organizational backbone for all physical examinations, clinical questionnaires, behavioral questionnaires, and laboratory assays, as well as all study clinic activities, including subject/dyad tracking and required reporting to health departments. Members of the Statistics/Computing Core will ensure the continued integrity of the Research Projects by overseeing data collection and ensuring the proper linkage of the various components of the STI TM CRC. These tasks will be accomplished through the use of a customized multi-functional database developed and maintained by Core personnel. In addition, the Statistical/Computing Core will provide expertise in computer hardware and software, including maintaining and upgrading all computer systems encompassed within the STI TM CRC. Finally, after data have been collected, members of the Statistical/Computing Core, with expertise in epidemiologic study design, statistical analysis techniques, and computer programming, will provide a central support system for all data analysis and interpretation activities undertaken by the Research Projects comprising the STI TM CRC, and will implement appropriate analytic methods for collaboratively addressing all Project Aims that involve statistical data analysis. Members of the Statistical/Computing Core will be closely integrated with each Project, providing specimen tracking and identification, as well as linkage of specimens across time within patients and dyads. Data collected at each visit for the Behavioral Project will be linked to results obtained from the Microbiology Research Projects and the Clinical Project in order to correlate laboratory findings with concurrent clinical, behavioral, situational, and other characteristics of the subjects. For the Behavioral Project in particular, Statistical/Computing Core personnel will be integrally involved at every step of the data analysis, including the assessment of intervention impact, the development of complex variable constructs, and the examination of numerous research questions relating to the understanding and prevention of STI transmission.

统计/计算核心是圣安东尼奥STI TM CRC提案中不可或缺的组成部分，为所有体检、临床问卷、行为问卷和实验室分析以及所有研究临床活动（包括受试者/双元跟踪和向卫生部门报告）提供数据收集和组织支柱。统计/计算组成员将监督数据收集，并确保科技及科技TM中心各组成部分之间的适当联系，以确保研究项目的持续完整性。这些任务将通过使用由核心人员开发和维护的定制多功能数据库来完成。此外，统计/计算核心将提供计算机硬件和软件方面的专业知识，包括维护和升级STI TM CRC内的所有计算机系统。最后，在收集数据后，统计/计算核心的成员将具有流行病学研究设计、统计分析技术和计算机编程方面的专业知识，为包括STI TM CRC在内的研究项目进行的所有数据分析和解释活动提供中央支持系统，并将实施适当的分析