University of Utah Pediatric Pharmacology Research Unit

描述(由申请人提供)： 这项申请是为了成为NICHD儿科药理学研究单位网络的成员，以增加对儿科受试者的药物研究，增加对药物代谢的发展变化的了解，并增加对儿科人群的药物标签。作为这项应用的一部分，我们建议研究吗啡的药代动力学及其在72小时输注过程中代谢成葡萄糖醛酸苷。吗啡的疗效将通过有效的疼痛评分和婴儿脑电的双谱分析来确定。另一项研究提出了一项随机、盲法比较，比较在机械通气期间使用芬太尼和吗啡用于镇静和止痛的新生儿的耐受性和戒断性的发展。耐受性的预测因素将基于暴露的药理学措施来确定。可乐定治疗新生儿戒断综合征的有效性将在开放标签治疗中确定。第三项研究将确定全身暴露于S-凯恩局部麻醉药贴片中的局麻药。

DESCRIPTION (provided by applicant): This is an application to become a member of the NICHD Pediatric Pharmacology Research Unit Network to increase the study of medications in pediatric subjects, increase understanding of developmental changes in drug metabolism, and increase labeling of drugs for the pediatric population. As part of this application, we propose to study the pharmacokinetics of morphine and its metabolism into glucuronides during a 72 hr infusion. The efficacy of morphine will be determined with validated pain scales and bispectral analysis of infant EEG. Another study proposes a randomized, blinded comparison of the development of tolerance and abstinence during treatment of neonates with fentanyl and morphine for sedation and analgesia during mechanical ventilation. Predictors of tolerance will be determined based on pharmacologic measures of exposure. The effectiveness of clonidine for treatment of abstinence syndrome in neonates will be determined in an open-label treatment. A third study will determine the systemic exposure to local anesthetics contained in the S-Caine topical local anesthetic patch.