犹他大学儿科药理学研究室-猫眼课题宝

犹他大学儿科药理学研究室

批准号：

7389722

负责人：

ROBERT MARSHALL WARD

金额：

$36.67万

依托单位：

UNIVERSITY OF UTAH

依托单位国家：

美国

项目类别：

财政年份：

2004

资助国家：

美国

项目状态：

已结题

起止时间：

2004-02-15 至 2010-12-31

来源：

https://reporter.nih.gov/project-details/7389722

关键词：

Absence of pain sensation Abstinence Abstinence Syndrome Adolescent Adult Adverse effects Adverse reactions Age Amendment Analgesics Area Award Biological Availability Biological Markers Blinded Cardiology Caring Characteristics Child Childhood Clinic Clinical Clinical Data Clinical Drug Development Clinical Research Clinical Trials Clonidine Communities Congestive Heart Failure Consult Contracts Data Data Analyses Development Developmental Disabilities Diagnosis Discipline Disease Disincentive Doctor of Medicine Dose Drug Delivery Systems Drug Formulations Drug Industry Drug Kinetics Drug Labeling Drug usage Educational process of instructing Effectiveness Electroencephalography End Point Environment Enzymes Ethical Issues Evaluation Exposure to Faculty Fentanyl Foundations Funding Genetic Polymorphism Genotype Glucuronides Goals Grant Growth Health Human Individual Infant Informed Consent Infusion procedures Invasive Joints Knowledge Label Laws Lead Leadership Legal patent Local Anesthetics Marketing Measurement Measures Mechanical ventilation Medical center Metabolism Modality Modeling Molecular Morphine Names National Institute of Child Health and Human Development Nature Newborn Infant Nurses Nursing Research Pain Parents Patients Pediatrics Pharmaceutical Preparations Pharmacists Pharmacodynamics Pharmacogenomics Pharmacologic Substance Pharmacology Pharmacy facility Phenotype Physicians Placebo Control Population Preclinical Drug Development Principal Investigator Proteomics Protocols documentation Public Health Qualifying Randomized Reaction Research Research Design Research Infrastructure Research Personnel Resources Risk Safety Sedation procedure Site Surrogate Markers Technology Testing Therapeutic Therapeutic Human Experimentation Toxic effect Toxicology Training United States United States Food and Drug Administration Universities Utah Validation base carvedilol college cost drug development drug metabolism experience glucuronide innovation member models and simulation neonate neuropsychiatry new technology novel novel strategies outcome forecast pediatric department pediatric pharmacology pediatrician pharmacokinetic model programs prospective receptor response stem tool ward

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DESCRIPTION (provided by applicant): This is an application to become a member of the NICHD Pediatric Pharmacology Research Unit Network to increase the study of medications in pediatric subjects, increase understanding of developmental changes in drug metabolism, and increase labeling of drugs for the pediatric population. As part of this application, we propose to study the pharmacokinetics of morphine and its metabolism into glucuronides during a 72 hr infusion. The efficacy of morphine will be determined with validated pain scales and bispectral analysis of infant EEG. Another study proposes a randomized, blinded comparison of the development of tolerance and abstinence during treatment of neonates with fentanyl and morphine for sedation and analgesia during mechanical ventilation. Predictors of tolerance will be determined based on pharmacologic measures of exposure. The effectiveness of clonidine for treatment of abstinence syndrome in neonates will be determined in an open-label treatment. A third study will determine the systemic exposure to local anesthetics contained in the S-Caine topical local anesthetic patch.

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