UCLA SPORE IN PROSTATE CANCER

描述(由申请人提供) 一个校园范围内的前列腺癌研究项目已经与 加州大学洛杉矶分校多所学校和研究所的合作。前列腺癌 程序区最近被命名为Jonsson的完整程序区 综合癌症中心(JCCC)。这一萌发方案提供了基础 对于这个孢子的应用。孢子的用途是，与其他 孢子机构，为诊断的进展做出贡献， 前列腺癌的预防和治疗。孢子项目有两个主要项目 目标： 1.开展多元翻译基础研究和社区化 以少数群体为重点的研究项目。四个实验室 研究项目将应用机构对基因表达和 信号转导，对前列腺癌的预后和治疗有指导意义。一个项目将 以机构调查人员的经验为基础，解决创新 前列腺癌饮食控制的几个方面。 2.发展新的前列腺癌研究和职业发展以推进 翻译研究。这将通过现有和继续实施 机构支持以及职业发展计划和发展 研究项目。 所有研究项目的重点都是快速转化为临床试验。 现有的临床研究计划已经得到协调，以提供最好的 可能获得研究前列腺癌所有阶段患者的机会。这个 四个基础研究项目是相互关联的，因为它们a)清楚地 可翻译，b)基于个人调查员的基本工作 自己的实验室，以及c)提供针对特定目标的新战略 前列腺癌中重要的信号通路。来自这些的信息 研究还提供了预后信息，并将增加目前的 局限性前列腺癌的临床和分子预后标志物。 一个外部咨询委员会将参与监督和分析 孢子在所有研究和行政领域的进展。在协作中 对于JCCC来说，孢子代表着一种重要的跨学科、协作性、 和翻译计划，承诺将对 前列腺癌死亡率和发病率。

DESCRIPTION (provided by applicant) A campus-wide Prostate Cancer Research Program has been developed with collaboration of multiple schools and institutes at UCLA. The Prostate Cancer Program area has recently been named a full Program Area of the Jonsson Comprehensive Cancer Center (JCCC). This germinal program provides the basis for this SPORE application. The purpose of the SPORE is, along with other SPORE institutions, to contribute to the progress in the diagnosis, prevention, and treatment of prostate cancer. The SPORE project has two major objectives: 1. To develop multiple translational basic research and community-based research projects with an emphasis on minority populations. Four laboratory research projects will apply institutional research on gene expression and signaling, to prognosis and treatment of prostate cancer. One project will build on the experience of institutional investigators to address innovative aspects of dietary control of prostate cancer. 2. To develop new prostate cancer research and career development to advance translational research. This will be effected through existing and continued institutional support as well as career development programs and developmental research programs. The emphasis in all research projects is rapid translation to clinical trials. Existing clinical research programs have been coordinated to provide the best possible access to study patients with all stages of prostate cancer. The four basic research projects are linked, in that they a) are clearly translatable, b) are based on basic work within the individual investigator's own laboratories, and c) provide new strategies for targeting specific signaling pathways important in prostate cancer. Information from these studies also provides prognostic information and will add to the current clinical and molecular markers of prognosis for localized prostate cancer. An external Advisory Board will participate in the supervision and analysis of SPORE progress in all research and administrative areas. In collaboration with the JCCC, the SPORE represents a major interdisciplinary, collaborative, and translational program which promises to make a significant impact on prostate cancer mortality and morbidity.