SPORE in Lung Cancer

描述(由申请人提供) 匹兹堡大学癌症研究所(UPCI)提议进行一项 肺癌卓越研究(孢子)专业计划。这个 UPCI型肺癌孢子的总体目标是提高检测和 肺癌的治疗及对其作用机制的认识 女性对肺癌的易感性。孢子计划将包括 肺癌五大翻译研究项目，三项研究 核心、管理核心、发展研究计划和职业 发展计划。加州大学伯克利分校的肺癌孢子将使用跨学科 通过与合作调查员共同开展项目来实现其目标的方法 在基础、应用和临床科学方面。它还具有器官特异性，因为它的 方法和所有项目都将测试关于肺癌生物学的假说， 敏感度、检测或治疗UPCI孢子的长期目标 是根据其翻译的研究结果进行临床试验 将作为改进成果的基础的研究项目 被诊断为肺癌的患者。五个主要项目是：(1) 胃泌素释放肽受体的表达与肺损伤的关系 癌症；(2)雌激素在肺癌发生发展中的作用；(3)细胞周期蛋白B1 作为非小细胞肺癌抗原；(4)对食道和正常肺的保护 非小细胞肿瘤的放化疗损伤与放射增敏 锰超氧化物歧化酶-质粒脂质体基因治疗肺癌的研究 治疗；(5)CT检出肺癌的分子流行病学。三位一体 研究核心将协助主要研究项目--发展研究 项目，和职业发展调查人员在开展肺癌 翻译研究。研究核心是组织和基因组学核心，以及 生物统计学核心。行政核心将提供科学和 对该计划的财政监督。UPCI孢子调查员将通力合作 作为一个团队来实现计划的目标，并将与 来自其他机构肺癌孢子的调查人员将改善结果 为肺癌患者准备的。

DESCRIPTION (provided by applicant) The University of Pittsburgh Cancer Institute (UPCI) proposes to conduct a Specialized Program of Research Excellence (SPORE) in Lung Cancer. The overall goals of the UPCI Lung Cancer SPORE are to improve detection and treatment of lung cancer and to understand the mechanisms of increased susceptibility of women to lung cancer. The SPORE program will consist of five major translational research projects in lung cancer, three research cores, an administrative core, a developmental research program, and a career development program. The UPCI Lung Cancer SPORE will use an interdisciplinary approach to meet its objectives by carrying out projects with co-investigators in basic, applied and clinical science. It is also organ-specific in its approach and all projects will test hypotheses about lung cancer biology, susceptibility, detection, or treatment. The long-term goal of the UPCI SPORE is to conduct clinical trials based on research results from its translational research projects that will serve as the basis for improving the outcome of patients diagnosed with lung cancer. The five main projects are: (1) Expression of Gastrin-Releasing Peptide Receptor as a Risk Factor for Lung Cancer; (2) Role of Estrogens in the Development of Lung Cancer; (3) Cyclin B1 as a Non-Small Lung Tumor Antigen; (4) Protection of Esophagus and Normal Lung from Chemoradiotherapy Damage with Radiosensitization of Tumor in Non-Small Cell Lung Cancer by Manganese Superoxide Distmutase-Plasmid Liposome Gene Therapy; (5) Molecular Epidemiology of CT-Detected Lung Cancer. The three research cores will assist the main research projects, developmental research projects, and career development investigators in carrying out lung cancer translational research. The research cores are Tissue and Genomics Core, and Biostatistics Core. The administrative core will provide scientific and fiscal oversight for the program. UPCI SPORE investigators will work together as a team to meet the goals of the program and will also interact with investigators from Lung Cancer SPORES at other institutions to improve outcome for lung cancer patients.