TARGETING EGFR AND GPCR SIGNALING IN SCCHN
TARGETING EGFR AND GPCR SIGNALING IN SCCHN
批准号:
6990399
负责人:
Jill M Siegfried
金额:
$20.54万
依托单位国家:
美国
项目类别:
财政年份:
2004
资助国家:
美国
项目状态:
已结题
起止时间:
2004-07-01 至 2009-06-30
关键词:
SDS polyacrylamide gel electrophoresisbiological signal transductionbradykinincarcinogenesis inhibitorcell growth regulationcell proliferationcell surface receptorsenzyme linked immunosorbent assayepidermal growth factorgene targetinggrowth factor receptorshead /neck neoplasmhuman tissueneoplasm /cancer therapyprostaglandin Eprotein signal sequencesquamous cell carcinomatissue /cell culturewestern blottings
中文摘要
描述(由申请人提供):头颈部鳞状细胞癌(SCCHN)已知是通过控制细胞的基因的复杂遗传和表观遗传改变而发展的
英文摘要
DESCRIPTION (provided by applicant): Squamous cell carcinoma of the head and neck (SCCHN) is known to develop through complex genetic and epigenetic alterations in genes that control cell
proliferation, cell cycle, and cell survival. One set of genes that shows frequently altered expression are genes for growth factors and their receptors, including Epidermal Growth Factor Receptor (EGFR). G-protein- coupled receptors (GPCRs) have been shown to activate the EGFR in SCCHN, resulting in increased proliferation and invasion. This proposal will address the effect on SCCHN cell growth and survival of GPCR signaling cascades that show a dual mechanism: one that is EGFR-independent, as well as one that is integrated with the EGFR. Our preliminary results suggest that two GPCR systems, prostaglandin E2 (PGE2) and its receptors, and bradykinin (BK) and its receptors, stimulate SCCHN proliferation by this dual mechanism. The overall goal of this proposal is to demonstrate the mechanism and importance of signaling through PGE2 and BK in head and neck cancer proliferation, and develop a rationale for combining inhibitors of these GPCR pathways with EGFR inhibitors for the treatment of SCCHN. The long-term goal is to design a clinical trial combining EGFR inhibitors with inhibitors of PGE2 or BK for head and neck cancer patients.
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资助金额:$18.5万
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SPORE in Lung Cancer
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资助金额:$230.0万
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资助金额:$222.07万
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SPORE in Lung Cancer
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资助金额:$2.6万
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海外基金