SPORE in Lung Cancer

描述（由申请人提供） 匹兹堡大学癌症研究所（UPCI）建议进行一项 肺癌卓越研究专业计划（SPORE）。的 UPCI肺癌孢子的总体目标是提高检测率， 肺癌的治疗和了解的机制增加 女性对肺癌的易感性。SPORE计划将包括 五个主要的肺癌转化研究项目，三个研究项目 核心，行政核心，发展研究计划和职业生涯 发展计划。UPCI肺癌孢子将使用跨学科的 通过与共同调查员开展项目实现其目标的方法 在基础、应用和临床科学中。它也是器官特异性的， 方法和所有项目将测试有关肺癌生物学的假设， 易感性、检测或治疗。UPCI SPORE的长期目标 是根据其转化的研究结果进行临床试验， 研究项目，将作为改善成果的基础， 肺癌的诊断五个主要项目是：（1） 胃泌素释放肽受体表达与肺损伤的关系 癌症;（2）雌激素在肺癌发展中的作用;（3）细胞周期蛋白B1 作为非小肺肿瘤抗原;（4）食管和正常肺的保护 非小细胞肺癌放化疗损伤与放射增敏 锰超氧化物歧化酶-质粒脂质体基因介导的肺癌 治疗;（5）CT检测肺癌的分子流行病学。三 研究核心将协助主要研究项目，发展研究， 项目和职业发展调查人员在开展肺癌 翻译研究研究核心是组织和基因组学核心， 生物统计学核心。行政核心将提供科学和 该计划的财政监督。UPCI SPORE调查人员将共同努力 作为一个团队，以满足该计划的目标，也将与 来自其他机构的肺癌研究者SPORES以改善结局 治疗肺癌的方法

DESCRIPTION (provided by applicant) The University of Pittsburgh Cancer Institute (UPCI) proposes to conduct a Specialized Program of Research Excellence (SPORE) in Lung Cancer. The overall goals of the UPCI Lung Cancer SPORE are to improve detection and treatment of lung cancer and to understand the mechanisms of increased susceptibility of women to lung cancer. The SPORE program will consist of five major translational research projects in lung cancer, three research cores, an administrative core, a developmental research program, and a career development program. The UPCI Lung Cancer SPORE will use an interdisciplinary approach to meet its objectives by carrying out projects with co-investigators in basic, applied and clinical science. It is also organ-specific in its approach and all projects will test hypotheses about lung cancer biology, susceptibility, detection, or treatment. The long-term goal of the UPCI SPORE is to conduct clinical trials based on research results from its translational research projects that will serve as the basis for improving the outcome of patients diagnosed with lung cancer. The five main projects are: (1) Expression of Gastrin-Releasing Peptide Receptor as a Risk Factor for Lung Cancer; (2) Role of Estrogens in the Development of Lung Cancer; (3) Cyclin B1 as a Non-Small Lung Tumor Antigen; (4) Protection of Esophagus and Normal Lung from Chemoradiotherapy Damage with Radiosensitization of Tumor in Non-Small Cell Lung Cancer by Manganese Superoxide Distmutase-Plasmid Liposome Gene Therapy; (5) Molecular Epidemiology of CT-Detected Lung Cancer. The three research cores will assist the main research projects, developmental research projects, and career development investigators in carrying out lung cancer translational research. The research cores are Tissue and Genomics Core, and Biostatistics Core. The administrative core will provide scientific and fiscal oversight for the program. UPCI SPORE investigators will work together as a team to meet the goals of the program and will also interact with investigators from Lung Cancer SPORES at other institutions to improve outcome for lung cancer patients.