Bench and Back: Clinical Biodetective Training (RMI)

描述（由申请人提供）： 这个新的博士前培训计划的目标是培养独立的跨学科科学家，他们将开发用于检测疾病状态，健康标志物和治疗标志物的新方法。虽然传统的生物医学研究方法已经取得了许多重大突破，但目前的提案将填补这一方法中的空白。传统的方法是以基础科学为中心，我们的方法是以临床为中心。我们将培训基础科学家，他们将熟练地了解临床需求，能够设计和制造设备，方法和化学品来满足这一需求，并且能够在活组织中测试这些设备，方法和化学品。本提案中的两个主要创新培训策略是与临床医生密切合作（例如，家庭执业医师、护士、内科临床医生和临床科学家）来识别与他们相关和重要的临床问题并且具有双重基础科学导师：在发明导师的实验室中将开发或构建设备或方法（例如，化学、工程、数学或物理导师），并且在生命科学导师的实验室中，将在生命系统中分析设备或方法（例如，生物化学，医学药理学和生理学，或兽医生物医学科学导师）。这种方法将是跨学科的，并将专注于解决重大的临床问题。它培养了首先从临床需求开始的基础科学家。这种方法补充了现有的传统的“板凳床旁转化研究”的培训方法，但需要它完整的循环。一个主要的创新是，我们还将考虑设备和方法，使我们能够从板凳到社区（即，在患者和临床医生不一定在医院环境中的情况下，可以在家庭实践环境中由护士和执业护士以及由患者用于自我监测的方法）。

DESCRIPTION (provided by applicant): The goal of this new predoctoral training program is to produce independent interdisciplinary scientists who will develop novel methods for the detection of disease states, markers of good health, and therapeutic markers. While the traditional biomedical research approach has led to many significant breakthroughs, there is a gap in this approach that the current proposal will fill. The traditional approach is basic-science centered; our approach is clinically-centered. We will train basic scientists who will be skilled in understanding clinical needs, who can design and build devices, approaches, and chemicals to fill this need, and who will be able to test these devices, approaches, and chemicals in living tissues. The two major innovative training strategies in this proposal are to work closely with clinicians (e.g., family practice physicians, nurses, internal medicine clinicians and clinical scientists) to identify clinical problems of relevance and significance to them and to have dual basic science mentors: in the invention mentor's lab the device or approach will be developed or built (e.g., Chemistry, Engineering, Math or Physics mentor) and in the life science mentor's lab the device or approach will be analyzed in a living system (e.g., Biochemistry, Medical Pharmacology and Physiology, or Veterinary Biomedical Sciences mentor). This approach will be interdisciplinary AND will be focused on solving significant clinical problems. It develops basic scientists who start with the clinical need first. This approach complements the existing traditional "bench to bedside translational research" training approach but takes it full circle. A major innovation is that we will also consider devices and approaches that will allow us to move from bench to community (i.e., approaches that can be used in family practice settings, by nurses and nurse practitioners, and by patients for self monitoring) in situations where the patient and clinician are not necessarily in a hospital setting.