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Exploring etiological factors underlying anxiety and its associations with physical health and health-related quality of life.

探索焦虑的病因及其与身体健康和健康相关生活质量的关系。

基本信息

批准号：
2339476
负责人：
金额：
--
依托单位：
King's College London
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2017
资助国家：
英国
起止时间：
2017 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=studentship-2339476
关键词：
Exploring etiological factors underlying anxiety

项目摘要

The first part of this project involves investigating the genetic and environmental architecture of anxiety symptoms in a twin sample (TWINS Study). We also explore associations between anxiety symptoms with a range of cardiac autonomic measures: inter-beat interval, heart rate variability and baroreflex sensitivity. This project adds to much needed behaviour genetics research on the relationships between anxiety and cardiovascular health. We aim to return to this twin dataset to further explore the associations between anxiety symptoms and potentially other internalizing symptoms (e.g. neuroticism, inter-personal sensitivity) and how it relates to physical health markers such as inflammation or metabolic markers. Our second key aim is to conduct twin analyses in a non-western population (CoTASS study, Sri-Lanka). Examining anxiety in both a western (high income countries, HIC) and non-western twin sample (low and middle-income countries, LMIC), will allow us to investigate whether it can manifest via cultural/environmental factors, giving this project a global-health angle. We aim to conduct bivariate twin analyses between anxiety symptoms and health-related quality of life in this sample, investigating phenotypic, genetic and environmental correlationships between the two domains. The third main component of the study involves investigating the epigenetic nature of anxiety. As anxiety disorders are commonly co-morbid with Autism Spectrum Disorder (ASD), we will be using an ongoing ASD twin dataset (Social Relationships Study; SRS) to compare epigenetic profiles with control participants. My aim is to investigate global DNA methylation, a novel research area especially in the context of anxiety pathology. Depending on sample and data availability, we also plan to make use of a different sample (GLAD study), specifically focusing on those with an anxiety/depression diagnosis, potentially for further genomic and epigenomic analyses.

该项目的第一部分涉及调查双胞胎样本中焦虑症状的遗传和环境结构（Tendon研究）。我们还探讨了焦虑症状与一系列心脏自主神经测量之间的关联：心跳间隔，心率变异性和压力反射敏感性。该项目增加了急需的行为遗传学研究焦虑和心血管健康之间的关系。我们的目标是回到这个双胞胎数据集，以进一步探索焦虑症状和潜在的其他内化症状（例如神经质，人际敏感）之间的关联，以及它如何与身体健康标志物（如炎症或代谢标志物）相关。我们的第二个关键目标是在非西方人群中进行双胞胎分析（CoTASS研究，斯里兰卡）。在西方（高收入国家，HIC）和非西方双样本（低收入和中等收入国家，LMIC）中检查焦虑，将使我们能够调查它是否可以通过文化/环境因素表现出来，使这个项目具有全球健康的角度。我们的目标是在这个样本中进行焦虑症状和健康相关生活质量之间的双变量双生子分析，调查这两个领域之间的表型，遗传和环境相关性。这项研究的第三个主要组成部分涉及调查焦虑的表观遗传性质。由于焦虑症通常与自闭症谱系障碍（ASD）共病，我们将使用正在进行的ASD双胞胎数据集（社会关系研究; SRS）与对照参与者比较表观遗传特征。我的目的是研究全球DNA甲基化，这是一个新的研究领域，特别是在焦虑病理学的背景下。根据样本和数据的可用性，我们还计划使用不同的样本（GLAD研究），特别关注那些患有焦虑/抑郁症的人，可能用于进一步的基因组和表观基因组分析。

项目成果

期刊论文数量（2）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Associations Between Anxiety Symptoms and Health-Related Quality of Life: A Population-Based Twin Study in Sri Lanka.

DOI：
10.1007/s10519-021-10051-1
发表时间：
2021-07
期刊：
Behavior genetics
影响因子：
2.6
作者：
Nas Z;Zavos HMS;Sumathipala A;Jayaweera K;Siribaddana S;Hotopf M;Rijsdijk FV
通讯作者：
Rijsdijk FV

Higher Anxiety Is Associated with Lower Cardiovascular Autonomic Function in Female Twins.

女性双胞胎中较高的焦虑程度与较低的心血管自主功能有关。