REGULATION OF INTRAOCULAR PRESSURE AND OCULAR BLOOD FLOW

眼内压和眼血流量的调节

• 批准号: 6693436
• 负责人: JOHN H LIU
• 金额: $ 46.85万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-11-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6693436
• 关键词: REGULATION; INTRAOCULAR; PRESSURE; OCULAR; BLOOD

DESCRIPTION (provided by applicant): Glaucoma is a leading cause of blindness. An elevated intraocular pressure (IOP) is a major risk factor. We have been studying the 24-hour pattern of IOP under strictly controlled laboratory conditions. Data have been collected from healthy young and elderly volunteers, from untreated glaucoma patients/suspects, and from glaucoma patients treated with timolol or latanoprost. In order to know whether or not surgical treatment sufficiently reduces IOP in glaucoma patients at night, we will study the 24-hour pattern of IOP in glaucoma patients receiving laser trabeculoplasty (Aim 1). An elevated IOP alters the ocular perfusion pressure and consequently may affect ocular blood flow. How the 24-hour variation of IOP affects ocular blood flow is unknown. Ocular blood flow may very well vary independently from IOP over the 24 hours. Therefore, we will study the 24-hour pattern of ocular blood flow in healthy individuals (Aim 2). Blood flow in the retrobulbar blood vessels will be characterized using the color Doppler imaging technique in the laboratory. Young and elderly volunteers will be selected based upon their home recordings of ambulatory blood pressure, sleep conditions, and IOP. Since an abnormal ocular blood flow may be another risk factor for glaucoma, we will study the 24-hour pattern of ocular blood flow in glaucoma patients (Aim 3). Similar home recordings will be performed to select representative glaucoma patients with excessive dipping of nocturnal blood pressure and with sleep apnea. Laboratory data will be collected from untreated glaucoma patients/suspects and from glaucoma patients receiving medical treatment with timolol or latanoprost and those surgically treated with laser trabeculoplasty. The long-term goal of the proposed studies is to define the endogenous mechanisms in the regulation of human IOP and ocular blood flow. Experimental results should provide fundamental information about how ocular blood flow is regulated during the day and at night in healthy individuals. New knowledge of ocular blood flow and IOP in patients would have implications for the better diagnosis and treatment of glaucoma.

描述（由申请人提供）：青光眼是导致失明的主要原因。眼内压（IOP）升高是一个主要的风险因素。我们一直在严格控制的实验室条件下研究IOP的24小时模式。数据收集自健康的年轻和老年志愿者、未经治疗的青光眼患者/疑似患者以及接受噻吗洛尔或拉坦前列素治疗的青光眼患者。为了了解手术治疗是否能充分降低青光眼患者夜间的IOP，我们将研究接受激光小梁成形术的青光眼患者的24小时IOP模式（目的1）。升高的IOP改变眼灌注压，因此可能影响眼血流。IOP的24小时变化如何影响眼部血流尚不清楚。在24小时内，眼血流量可以非常独立于IOP而变化。因此，我们将研究健康个体的24小时眼血流模式（目的2）。将在实验室中使用彩色多普勒成像技术表征球后血管中的血流。将根据其动态血压、睡眠状况和IOP的家庭记录选择年轻和老年志愿者。由于眼部血流异常可能是青光眼的另一个危险因素，我们将研究青光眼患者的24小时眼部血流模式（目的3）。将进行类似的家庭记录，以选择夜间血压过度下降和睡眠呼吸暂停的代表性青光眼患者。将从未经治疗的青光眼患者/疑似青光眼患者和接受噻吗洛尔或拉坦前列素药物治疗的青光眼患者以及接受激光小梁成形术手术治疗的青光眼患者中收集实验室数据。 拟定研究的长期目标是确定调节人IOP和眼血流的内源性机制。实验结果应该提供关于健康个体在白天和晚上如何调节眼血流的基本信息。对患者眼血流和眼压的新认识将对青光眼的更好诊断和治疗产生影响。