REGULATION OF INTRAOCULAR PRESSURE AND OCULAR BLOOD FLOW

眼内压和眼血流量的调节

• 批准号: 7171804
• 负责人: JOHN H LIU
• 金额: $ 50.49万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-11-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7171804
• 关键词: Affect; Antihypertensive Agents; Attention; Blindness; Blood Pressure; Blood Vessels; Blood flow; Color; Condition; Data; Diagnosis; Elderly; Elevation; Endogenous Factors; Eye; Glaucoma; Goals; Home environment; Hour; Human; Image; Imaging Techniques; Individual; Invasive; Knowledge; Laboratories; Lasers; Latanoprost; Medical; Newly Diagnosed; Ocular Hypertension; Operative Surgical Procedures; Patient Representative; Patients; Pattern; Perfusion; Physiologic Intraocular Pressure; Play; Positioning Attribute; Posture; Regulation; Research; Risk Factors; Role; Sleep; Sleep Apnea Syndromes; Suspect Glaucomas; Techniques; Time; Timolol; Trabeculectomy; Ultrasonography; Variant; base; day; ocular hypotensive; pressure; research study; volunteer

Glaucoma is a leading cause of blindness. An elevated intraocular pressure (lOP) is a major risk factor. We have been studying the 24-hour pattern of lOP under strictly controlled laboratory conditions. Data have been collected from healthy young and elderly volunteers, from untreated glaucoma patients/suspects, and from glaucoma patients treated with timolol or latanoprost. In order to know whether or not surgical treatment sufficiently reduces lOP in glaucoma patients at night, we will study the 24-hour pattern of lOP in glaucoma patients receiving laser trabeculoplasty (Aim 1). An elevated lOP alters the ocular perfusion pressure and consequently may affect ocular blood flow. How the 24-hour variation of lOP affects ocular blood flow is unknown. Ocular blood flow may very well vary independently from lOP over the 24 hours. Therefore, we will study the 24-hour pattern of ocular blood flow in healthy individuals (Aim 2). Blood flow in the retrobulbar blood vessels will be characterized using the color Doppler imaging technique in the laboratory. Young and elderly volunteers will be selected based upon their home recordings of ambulatory blood pressure, sleep conditions, and lOP. Since an abnormal ocular blood flow may be another risk factor for glaucoma, we will study the 24-hour pattern of ocular blood flow in glaucoma patients (Aim 3). Similar home recordings will be performed to select representative glaucoma patients with excessive dipping of nocturnal blood pressure and with sleep apnea. Laboratory data will be collected from untreated glaucoma patients/suspects and from glaucoma patients receiving medical treatment with timolol or latanoprost and those surgically treated with laser trabeculoplasty. The long-term goal of the proposed studies is to define the endogenous mechanisms in the regulation of human lOP and ocular blood flow. Experimental results should provide fundamental information about how ocular blood flow is regulated during the day and at night in healthy individuals. New knowledge of ocular blood flow and lOP in patients would have implications for the better diagnosis and treatment of glaucoma.

青光眼是导致失明的主要原因。眼内压（IOP）升高是一个主要的风险因素。 我们一直在严格控制的实验室条件下研究lOP的24小时模式。数据具有 从健康的年轻和老年志愿者、未经治疗的青光眼患者/疑似患者中收集， 来自用噻吗洛尔或拉坦前列素治疗的青光眼患者。为了知道是否手术治疗 充分降低青光眼患者夜间IOP，我们将研究青光眼患者24小时IOP模式 接受激光小梁成形术的患者（目标1）。升高的IOP改变眼灌注压， 因此可能影响眼部血流。IOP的24小时变化如何影响眼部血流， 未知在24小时内，眼血流量可以非常独立于IOP而变化。所以我们会 研究健康人眼血流的24小时模式（目的2）。眼球后血流 将在实验室中使用彩色多普勒成像技术表征血管。年轻和 老年志愿者将根据他们的动态血压、睡眠、血压和血压的家庭记录来选择。 条件和IOP。由于眼部血流异常可能是青光眼的另一个危险因素，我们将 目的3：研究青光眼患者眼血流24小时模式。类似的家庭录音将在 选择夜间血压过度下降的代表性青光眼患者进行 还有睡眠呼吸暂停实验室数据将从未经治疗的青光眼患者/疑似患者和 接受噻吗洛尔或拉坦前列素药物治疗的青光眼患者和接受 激光小梁成形术 拟议研究的长期目标是确定调节的内源性机制， 人IOP和眼血流量。实验结果应该提供基本信息， 在健康个体中，眼血流在白天和晚上受到调节。眼科新知识 患者的血流量和IOP对于更好地诊断和治疗青光眼具有意义。

项目成果

Relationship of the 24-hour pattern of intraocular pressure with optic disc appearance in primary open-angle glaucoma.

• DOI: 10.1016/j.ophtha.2008.10.034
• 发表时间: 2009-05
• 期刊: Ophthalmology
• 影响因子: 13.7
• 作者: Deokule SP;Doshi A;Vizzeri G;Medeiros FA;Liu JH;Bowd C;Zangwill L;Weinreb RN
• 通讯作者: Weinreb RN

Sustained effect of travoprost on diurnal and nocturnal intraocular pressure.

曲伏前列素对昼夜眼压的持续影响。

• DOI: 10.1016/j.ajo.2006.01.049
• 发表时间: 2006
• 期刊: American journal of ophthalmology.
• 作者: Sit,ArthurJ;Weinreb,RobertN;Crowston,JonathanG;Kripke,DanielF;Liu,JohnHK
• 通讯作者: Liu,JohnHK

Physiological factors in the circadian rhythm of protein concentration in aqueous humor.

房水中蛋白质浓度昼夜节律的生理因素。

• 发表时间: 1998
• 期刊: Investigative ophthalmology & visual science.
• 作者: Liu,JH;Lindsey,JD;Weinreb,RN
• 通讯作者: Weinreb,RN

Circadian variation of mouse aqueous humor protein.

小鼠房水蛋白的昼夜节律变化。

• 发表时间: 2006
• 期刊: Molecular vision [electronic resource].
• 作者: Zhou,LindaX;Liu,JohnHK
• 通讯作者: Liu,JohnHK

Twenty-four-hour pattern of intraocular pressure in the aging population.

• 发表时间: 1999-11
• 期刊: Investigative ophthalmology & visual science
• 影响因子: 4.4
• 作者: John H. K. Liu;D. Kripke;M. Twa;R. Hoffman;S. Mansberger;K. M. Rex;C. Girkin;R. Weinreb