Modelling heat impact on human hard and soft tissue in pulsed laser ablation

模拟脉冲激光烧蚀对人体硬组织和软组织的热影响

• 批准号: 2342050
• 金额: --
• 依托单位: Heriot-Watt University
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2342050
• 关键词: Modelling; heat; impact; human; hard

"This is a PhD research project in mechanical engineering, specifically tissue biomechanics.Background: Cancer or musculoskeletal diseases affect millions of people in ageing societies worldwide. Modern treatment strategies, especially in pre-metastatic stages, often employ resections, which are carried out using minimal invasive access procedures. Laser ablation based dissection is supposed to be a "cold" process with minimal impact on the surrounding tissue. Likewise, laser ablation is used to prepare micron-sized biopsies that, in turn, inform the development of new treatment technologies in preclinical research. However, little is known about the heat impact on the material during the ablation process for the diverse range of tissues that may be potentially treated.Project: Therefore, this project aims at developing a technology that allows to investigating the heat impact during pulsed laser ablation on different tissues specific to clinical and pre-clinical application. An example could be laser ablation of liver metastases or brain tumour treatment. Key tasks include:(i) develop a simulation suite, e.g. finite elements, to evaluate the heat impact of pulsed laser ablation on different hard and soft tissue based on initial work on bones extra-cellular matrix,(ii) verify and validate the simulation suite, (iii) use this simulation suite to identify a admissible operating parameters that do not damage surrounding material for clinical and pre-clinical challenges.Impact: If successful, this project will have a direct, positive impact on minimal invasive surgery technologies. In addition, the results will impact state of the art preparation strategies for micromechanical testing."

这是一个机械工程学的博士研究项目，特别是组织生物力学。背景：癌症或肌肉骨骼疾病影响着全球老龄化社会的数百万人。现代的治疗策略，特别是在转移前阶段，通常采用切除，这是使用微创进入程序进行的。基于激光消融的解剖被认为是一个对周围组织影响最小的“冷”过程。同样，激光消融被用来准备微米大小的活检组织，进而为临床前研究中新治疗技术的发展提供信息。然而，对于可能治疗的各种组织在消融过程中对材料的热影响知之甚少。项目：因此，该项目旨在开发一种技术，允许研究脉冲激光消融过程中对不同组织的热影响，特定于临床和临床前应用。例如，激光消融治疗肝转移瘤或脑瘤。主要任务包括：(I)开发一个模拟套件，例如有限元，基于对骨骼细胞外基质的初步工作，评估脉冲激光消融对不同硬组织和软组织的热影响，(Ii)验证和验证模拟套件，(Iii)使用该模拟套件确定可接受的、不损害临床和临床前材料的操作参数。影响：如果该项目成功，将对微创外科技术产生直接的积极影响。此外，测试结果还将影响微机械测试的最先进准备策略。“