Experimental Hematology-Immunology

描述(由申请人提供)：杰克逊实验室(TJL)的科学家们长期以来一直认为有必要培训一批研究科学家，了解完整动物模型系统中免疫学和血液学问题的遗传基础的复杂性。这一理念是实验室战略计划中不可或缺的一部分，它规定了TJL正在不断扩大整体培训计划。杰克逊实验室要求为其完善的免疫学和血液学博士后研究培训计划的继续提供资金。TJL研究人员的11名成员组成了一个跨学科的受训教官队伍，他们正在研究小鼠造血和淋巴细胞途径中的基因调控和细胞发展。在这些基因定义的动物模型中的实验工作提供了机会来测试关于免疫和血液疾病的遗传基础的假说，并建立新的诊断和治疗模式的模型。由于实验室拥有无与伦比的特殊近亲繁殖、自发和诱变小鼠的资源库，这些类型的分析成为可能。TJL博士后项目(4名实习生)。学员主要致力于板凳研究，并融入TJL研讨会、课程、工作坊和研究兴趣小组。他们被要求撰写奖学金申请，并在内部利益小组和国际会议上展示他们的结果。他们的进展由一个正式的培训委员会监督，每个成员都是几名受训人员的非正式导师或联络人。完成培训后，学员将有资格在大学、研究机构或行业从事血液学和免疫学方面的创造性独立研究。在上一次报告所述期间，这笔赠款资助的所有受训人员都获得了独立研究金，这部分证明了该方案的持续质量。主要的培训机构是TJL，这是一家私人的独立研究中心。TJL是NIH基础癌症研究中心，每年饲养300万只小鼠，自1956年以来一直持有NIH研究培训补助金。

DESCRIPTION (provided by applicant):Scientists at The Jackson Laboratory (TJL) have long seen the need to train a cadre of research scientists in the complexity of the genetic basis of immunological and hematological problems in intact animal model systems. This philosophy, an integral part of the Laboratory's Strategic Plan, has dictated the ongoing expansion of the overall training program at TJL. The Jackson Laboratory requests funding for continuation of its well-established postdoctoral research training program in immunology and hematology. Eleven members of the TJL Research Staff form an interdisciplinary pool of trainee preceptors who are investigating gene regulation and cell development in hemopoietic and lymphoid cell pathways in the mouse. Experimental work in these genetically-defined animal models provides the opportunity to test hypotheses regarding the genetic basis of immunological and hematological disorders and to model new diagnostic and therapeutic modalities. These types of analyses are made possible by the availability of the Laboratory's unparalleled resource base of special inbred, spontaneous and induced-mutant mice. TJL Postdoctoral program (4 trainees). Trainees devote their major effort to bench research, and are integrated into TJL seminars, courses, workshops, and research interest groups. They are required to write fellowship applications, and present their results both at in-house interest groups and international meetings. Their progress is overseen by a formal Training Committee, each member of which acts as an informal mentor, or liaison, for several trainees. Upon completion of training, participants will be qualified to engage in creative, independent research in hematology and immunology at a university, research institution, or in industry. The continued quality of the program is evidenced in part by the fact that all of the trainees supported by this grant in the last reporting period obtained independent fellowships. The primary training facility is TJL, a private, independent research center. TJL is an NIH Basic Cancer Research Center, raises 3 million mice annually, and has held NIH research training grants continuously since 1956.