Experimental Hematology-Immunology

描述（由申请人提供）：杰克逊实验室（TJL）的科学家长期以来一直认为有必要培养一批研究科学家，研究完整动物模型系统中免疫和血液学问题遗传基础的复杂性。这一理念是实验室战略计划的一个组成部分，决定了TJL整体培训计划的持续扩展。杰克逊实验室为其完善的免疫学和血液学博士后研究培训计划的继续申请资助。TJL研究人员的11名成员组成了一个跨学科的培训导师池，他们正在研究小鼠造血和淋巴细胞途径中的基因调控和细胞发育。在这些遗传定义的动物模型中进行的实验工作为检验有关免疫和血液疾病遗传基础的假设以及建立新的诊断和治疗模式提供了机会。这些类型的分析是由于实验室无与伦比的特殊近交、自发和诱导突变小鼠资源基础的可用性而成为可能。TJL博士后流动站（培养4人）。学员将主要精力投入到实验研究中，并被纳入TJL的研讨会、课程、讲习班和研究兴趣小组。他们被要求撰写奖学金申请，并在内部兴趣小组和国际会议上展示他们的成果。他们的进展由一个正式的培训委员会监督，该委员会的每一位成员都充当几名受训者的非正式导师或联络人。培训结束后，参与者将有资格在大学、研究机构或行业从事血液和免疫学方面的创造性、独立研究。在上一个报告所述期间，得到这笔赠款支助的所有受训人员都获得了独立研究金，这一事实部分证明了该方案的持续质量。主要的培训机构是TJL，一个私人的、独立的研究中心。TJL是美国国立卫生研究院的基础癌症研究中心，每年饲养300万只小鼠，自1956年以来一直获得美国国立卫生研究院的研究培训资助。

DESCRIPTION (provided by applicant):Scientists at The Jackson Laboratory (TJL) have long seen the need to train a cadre of research scientists in the complexity of the genetic basis of immunological and hematological problems in intact animal model systems. This philosophy, an integral part of the Laboratory's Strategic Plan, has dictated the ongoing expansion of the overall training program at TJL. The Jackson Laboratory requests funding for continuation of its well-established postdoctoral research training program in immunology and hematology. Eleven members of the TJL Research Staff form an interdisciplinary pool of trainee preceptors who are investigating gene regulation and cell development in hemopoietic and lymphoid cell pathways in the mouse. Experimental work in these genetically-defined animal models provides the opportunity to test hypotheses regarding the genetic basis of immunological and hematological disorders and to model new diagnostic and therapeutic modalities. These types of analyses are made possible by the availability of the Laboratory's unparalleled resource base of special inbred, spontaneous and induced-mutant mice. TJL Postdoctoral program (4 trainees). Trainees devote their major effort to bench research, and are integrated into TJL seminars, courses, workshops, and research interest groups. They are required to write fellowship applications, and present their results both at in-house interest groups and international meetings. Their progress is overseen by a formal Training Committee, each member of which acts as an informal mentor, or liaison, for several trainees. Upon completion of training, participants will be qualified to engage in creative, independent research in hematology and immunology at a university, research institution, or in industry. The continued quality of the program is evidenced in part by the fact that all of the trainees supported by this grant in the last reporting period obtained independent fellowships. The primary training facility is TJL, a private, independent research center. TJL is an NIH Basic Cancer Research Center, raises 3 million mice annually, and has held NIH research training grants continuously since 1956.