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Mark I, Model 68A Cesium 137 Research Irradiator

Mark I, Model 68A Cesium 137 Research Irradiator
Mark I,68A 型铯 137 研究辐照器
批准号:
6578614
负责人:
ROBERT Frank PAULSON
金额:
$19.44万
依托单位国家:
美国
项目类别:
财政年份:
2003
资助国家:
美国
项目状态:
已结题
起止时间:
2003-05-01 至 2004-04-30

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英文摘要
DESCRIPTION (provided by applicant): Via NIH's Shared Instrumentation Grant Program, funds are requested to purchase a Cesium-137 irradiator designed for the whole body irradiation of mice. Major research applications are 1) Ablation of host bone marrow prior to transplantation; 2) Irradiation of antigen presenting cells in studies of T cell activation and development; and 3) Tests of ionizing radiation on the action of specifically mutated proto-oncogenes. This Cesium-137 irradiator would benefit a users group of 14 investigators in the following specific areas: B and T cell development and studies of TCR activation; macrophage mediated inflammation and wound healing; erythropoiesis and erythropoietin receptor signaling; and molecular mechanisms of proto-oncogene and viral oncogene action, including studies of Friend virus gp55, Sf-Stk, PPARb and Patched, and Piml.
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Metabolic Regulation of erythropoiesis
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海外基金