Gammacell 220 High Dose Rate Irradiator

描述（由申请人提供）：我们正在申请资金购买一个新的Gammacell 220 Excel自包含高剂量率研究辐照器，作为麻省理工学院生物医学研究的共享仪器。该仪器是辐射设施的核心，用于研究辐射对生物系统的影响。除主要研究者外，还有8名共同申请人迫切需要高剂量率辐射源，用于干细胞研究、免疫功能和神经生物学、毒理基因组学、遗传毒理学和生物化学等研究。对这种设备的迫切需求直接来自于这样一个事实，即高剂量率Gammacell将使我们能够进行研究，否则是不可能的。Gammacell的收购将提供一个宝贵的资源，不仅为科学家参与这项拨款申请，而且为教师和学生在麻省理工学院校园和波士顿/剑桥科学界，因为有没有类似的设备在该地区。除了主要研究者和共同申请人所代表的学科外，Gammacell辐射源也将引起麻省理工学院材料科学与工程系非NIH资助科学家的兴趣（对包装、一次性医疗用品、军服、航天器等中使用的新型材料的辐射效应），航空航天工程（空间电子设备的鉴定）和核工程（剂量测定校准）。

DESCRIPTION (provided by applicant): We are requesting funds to purchase a new Gammacell 220 Excel Self-contained High Dose Rate Research Irradiator as a shared instrument for biomedical research at MIT. The instrument represents the centerpiece of a radiation facility for state-of-the-art studies of the effects of radiation on biological systems. In addition to the Principal Investigator, there are eight Co-Applicants who have a critical need for a high dose-rate radiation source for studies ranging from stem cell research, immune function, and neurobiology, to toxicogenomics, genetic toxicology, and biochemistry. The critical need for this device arises directly from the fact that the high dose-rate Gammacell will allow us to pursue studies that would otherwise not be possible. The acquisition of the Gammacell will provide a valuable resource not only for the scientists participating in this grant application, but also for faculty and students across the MIT campus and in the Boston/Cambridge scientific community, since there exists no similar device in the area. In addition to the disciplines represented by the Principal Investigator and the Co-Applicants, the Gammacell radiation source will also be of interest to MIT scientists with non-NIH funding in the Departments of Materials Science and Engineering (radiation effects on novel materials used in packaging, medical disposables, military uniforms, space vehicles, etc.), Aerospace Engineering (qualification of space-bound electronics), and Nuclear Engineering (dosimetry calibration).