13th International Workshop on Radiation Damage to DNA

第13届DNA辐射损伤国际研讨会

• 批准号: 8720445
• 负责人: Peter C Dedon
• 金额: $ 0.65万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8720445
• 关键词: Address; African American; Biological; Biology; Cancerous; Cell Death; Chemicals; Chemistry; Chromatin; Clinical; Clinical Oncology; Communities; DNA; DNA Damage; DNA Double Strand Break; DNA Repair; DNA lesion; Deposition; Development; Diagnosis; Discipline; Educational workshop; Epigenetic Process; Exposure to; Faculty; Genome; Genomic Instability; Goals; Health Policy; Institutes; Institution; International; Ionizing radiation; Lesion; Low Dose Radiation; Massachusetts; Medicine; Mentors; Modeling; Molecular; Mutation; Oral; Outcome; Participant; Pathway interactions; Physics; Postdoctoral Fellow; Prevention; Production; Public Health; Radiation; Radiation Induced DNA Damage; Radiation induced damage; Radiation therapy; Radiobiology; Radiochemistry; Radiosensitization; Request for Applications; Research; Research Personnel; Risk Assessment; Science; Scientist; Senior Scientist; Series; Structure; Technology; Therapeutic; Therapeutic Effect; Thinking; Time; Toxic effect; Translating; Translational Research; Travel; Woman; career; disorder prevention; exposed human population; graduate student; interest; intimate behavior; lectures; meetings; member; nanoparticle; oxidation; posters; programs; public health relevance; repaired; symposium; tool

DESCRIPTION (provided by applicant): This application requests support for 13th International Workshop on Radiation Damage to DNA to be held at the Massachusetts Institute of Technology in Cambridge, MA, from June 14 through June 18, 2014. This will be the thirteenth in a highly successful series of uniquely interdisciplinary workshops that bring together the leading experts in physics, chemistry, biology and medicine who have an interest in understanding the effects of ionizing radiation on DNA and in translating the research ideas to clinical and public health outcomes in prevention, diagnosis and therapy. The participants, limited to 150, will be from diverse academic and research institutions and will include graduate students, postdoctoral fellows, and early-career and senior scientists. A unique feature of this program is its breadth of topics ranging from physical energy deposition of ionizing radiation in DNA through to the ultimate biological outcome. In 15 sessions with two Keynote Lectures and two poster sessions, the Workshop introduces new topics such as the biology of space radiation, the epigenetics of radiation biology, synthetic lethality in radiotherapy, therapeutic radiomitigators and radiosensitization by high-Z nanoparticles, and the biological impact of low-dose radiation. The Workshop also addresses the latest developments in the physics and modeling of radiation tracks, molecular damage and DNA repair; the chemistry of radiation-induced DNA oxidation; the chemical mechanisms and biological consequences of clustered DNA damage and damage to chromatin; repair of radiation-induced DNA double-strand breaks and clustered lesions; new tools for studying DNA repair in real time; and a memorial symposium to honor a pioneer in radiation chemical biology, Clemens von Sonntag. The intimacy of the Workshop format promotes discussion of the mechanisms involved in the production of DNA lesions, the ultimate biological consequences of those lesions, and pathways to disease prevention, diagnosis and therapy. Although the focus spans physics, chemistry and biology, an important goal of this meeting is to decrease polarization by discipline and stimulate new, interdisciplinary thinking and experimental approaches. Along with invited presentations and poster sessions organized to promote formal and informal discussions, the Workshop structure emphasizes the participation of young investigators with an oral presentation in each session for graduate students, postdoctoral fellows and junior faculty, and encourages their professional development by mentoring and networking with senior researchers.

说明（由申请人提供）：本申请请求支持将于 2014 年 6 月 14 日至 18 日在马萨诸塞州剑桥麻省理工学院举办的第 13 届 DNA 辐射损伤国际研讨会。这将是一系列非常成功的独特跨学科研讨会中的第 13 次研讨会，这些研讨会汇集了对了解电离辐射对 DNA 的影响感兴趣的物理、化学、生物学和医学领域的领先专家 并将研究理念转化为预防、诊断和治疗方面的临床和公共卫生成果。参与者仅限于 150 人，将来自不同的学术和研究机构，包括研究生、博士后研究员以及职业生涯早期和资深科学家。该项目的一个独特之处在于其主题广泛，从 DNA 中电离辐射的物理能量沉积到最终的生物学结果。研讨会共 15 场会议，包括两场主题演讲和两场海报会议，介绍了新的主题，例如空间辐射生物学、辐射生物学的表观遗传学、放射治疗中的合成致死性、治疗性放射缓解剂和高 Z 纳米粒子的放射增敏作用，以及低剂量辐射的生物影响。研讨会还讨论了辐射轨迹、分子损伤和 DNA 修复的物理和建模的最新进展；辐射诱导 DNA 氧化的化学；簇状 DNA 损伤和染色质损伤的化学机制和生物学后果；修复辐射引起的 DNA 双链断裂和聚集性损伤；实时研究 DNA 修复的新工具；以及纪念放射化学生物学先驱克莱门斯·冯·桑塔格（Clemens von Sonntag）的纪念研讨会。研讨会的亲密形式促进了对 DNA 损伤产生机制、这些损伤的最终生物学后果以及疾病预防、诊断和治疗途径的讨论。尽管焦点涵盖物理、化学和生物学，但本次会议的一个重要目标是减少学科两极分化并激发新的跨学科思维和实验方法。除了为促进正式和非正式讨论而组织的受邀演讲和海报会议之外，研讨会的结构还强调年轻研究人员的参与，并在每次会议上为研究生、博士后研究员和初级教师进行口头演讲，并通过指导和与高级研究人员建立联系来鼓励他们的专业发展。