13th International Workshop on Radiation Damage to DNA

第13届DNA辐射损伤国际研讨会

• 批准号: 8720445
• 负责人: Peter C Dedon
• 金额: $ 0.65万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8720445
• 关键词: Address; African American; Biological; Biology; Cancerous; Cell Death; Chemicals; Chemistry; Chromatin; Clinical; Clinical Oncology; Communities; DNA; DNA Damage; DNA Double Strand Break; DNA Repair; DNA lesion; Deposition; Development; Diagnosis; Discipline; Educational workshop; Epigenetic Process; Exposure to; Faculty; Genome; Genomic Instability; Goals; Health Policy; Institutes; Institution; International; Ionizing radiation; Lesion; Low Dose Radiation; Massachusetts; Medicine; Mentors; Modeling; Molecular; Mutation; Oral; Outcome; Participant; Pathway interactions; Physics; Postdoctoral Fellow; Prevention; Production; Public Health; Radiation; Radiation Induced DNA Damage; Radiation induced damage; Radiation therapy; Radiobiology; Radiochemistry; Radiosensitization; Request for Applications; Research; Research Personnel; Risk Assessment; Science; Scientist; Senior Scientist; Series; Structure; Technology; Therapeutic; Therapeutic Effect; Thinking; Time; Toxic effect; Translating; Translational Research; Travel; Woman; career; disorder prevention; exposed human population; graduate student; interest; intimate behavior; lectures; meetings; member; nanoparticle; oxidation; posters; programs; public health relevance; repaired; symposium; tool

DESCRIPTION (provided by applicant): This application requests support for 13th International Workshop on Radiation Damage to DNA to be held at the Massachusetts Institute of Technology in Cambridge, MA, from June 14 through June 18, 2014. This will be the thirteenth in a highly successful series of uniquely interdisciplinary workshops that bring together the leading experts in physics, chemistry, biology and medicine who have an interest in understanding the effects of ionizing radiation on DNA and in translating the research ideas to clinical and public health outcomes in prevention, diagnosis and therapy. The participants, limited to 150, will be from diverse academic and research institutions and will include graduate students, postdoctoral fellows, and early-career and senior scientists. A unique feature of this program is its breadth of topics ranging from physical energy deposition of ionizing radiation in DNA through to the ultimate biological outcome. In 15 sessions with two Keynote Lectures and two poster sessions, the Workshop introduces new topics such as the biology of space radiation, the epigenetics of radiation biology, synthetic lethality in radiotherapy, therapeutic radiomitigators and radiosensitization by high-Z nanoparticles, and the biological impact of low-dose radiation. The Workshop also addresses the latest developments in the physics and modeling of radiation tracks, molecular damage and DNA repair; the chemistry of radiation-induced DNA oxidation; the chemical mechanisms and biological consequences of clustered DNA damage and damage to chromatin; repair of radiation-induced DNA double-strand breaks and clustered lesions; new tools for studying DNA repair in real time; and a memorial symposium to honor a pioneer in radiation chemical biology, Clemens von Sonntag. The intimacy of the Workshop format promotes discussion of the mechanisms involved in the production of DNA lesions, the ultimate biological consequences of those lesions, and pathways to disease prevention, diagnosis and therapy. Although the focus spans physics, chemistry and biology, an important goal of this meeting is to decrease polarization by discipline and stimulate new, interdisciplinary thinking and experimental approaches. Along with invited presentations and poster sessions organized to promote formal and informal discussions, the Workshop structure emphasizes the participation of young investigators with an oral presentation in each session for graduate students, postdoctoral fellows and junior faculty, and encourages their professional development by mentoring and networking with senior researchers.

描述(由申请人提供)：本申请请求支持将于2014年6月14日至6月18日在马萨诸塞州剑桥市麻省理工学院举行的第13届国际DNA辐射损伤研讨会。这将是一系列非常成功的独特跨学科研讨会中的第十三次，这些研讨会聚集了物理、化学、生物和医学领域的领先专家，他们有兴趣了解电离辐射对DNA的影响，并将研究想法转化为预防、诊断和治疗方面的临床和公共卫生成果。参与者不超过150人，将来自不同的学术和研究机构，包括研究生、博士后研究员、职业生涯早期和高级科学家。这个项目的一个独特特点是它的主题范围广泛，从DNA中电离辐射的物理能量沉积到最终的生物结果。在两次主题讲座和两次海报会议的15次会议中，讲习班介绍了空间辐射生物学、辐射生物学的表观遗传学、放射治疗中的合成致命性、治疗性放射增敏剂和高Z纳米粒子的放射增敏以及低剂量辐射的生物影响等新主题。讲习班还讨论了以下方面的最新进展：辐射径迹、分子损伤和DNA修复的物理和模拟；辐射诱导的DNA氧化的化学；DNA簇状损伤和染色质损伤的化学机制和生物学后果；辐射引起的DNA双链断裂和簇状损伤的修复；实时研究DNA修复的新工具；以及纪念辐射化学生物学先驱克莱门斯·冯·桑塔格的座谈会。讲习班形式的亲密性促进了对DNA损伤产生的机制、这些损伤的最终生物学后果以及疾病预防、诊断和治疗途径的讨论。尽管会议的重点涉及物理、化学和生物，但这次会议的一个重要目标是减少学科之间的两极分化，并激发新的、跨学科的思维和实验方法。除了为促进正式和非正式讨论而组织的特邀演讲和海报会议外，讲习班结构还强调年轻研究人员的参与，在每一次会议上为研究生、博士后研究员和初级教员进行口头介绍，并通过指导高级研究人员和与高级研究人员建立网络来鼓励他们的专业发展。