Advanced Research Cooperation In Environmental Health S*

环境健康高级研究合作 S*

• 批准号: 6644901
• 负责人: Romonia Renee REAMS
• 金额: $ 92.49万
• 依托单位: FLORIDA AGRICULTURAL AND MECHANICAL UNIV
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-25 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6644901
• 关键词: biological signal transduction; environmental health; environmental toxicology; minority institution research support

DESCRIPTION (provided by applicant): Faculty members at Florida A&M University (FAMU), in partnership with faculty in the Institute of Chemical Toxicology and Environmental Health Science (EHS) Center in Molecular and Cellular Toxicology with Human Applications at Wayne State University are proposing an advanced research cooperation program in basic environmental health sciences. This program will provide the infrastructure required for mentoring and developing Florida A&M faculty in the use of contemporary concepts in molecular and cell biology and related experimental approaches and technologies such that these investigators will be able to pursue studies of the molecular mechanisms by which environmental chemicals modulate the response of cells and tissues. The research focus of investigators in this initiative is signal transduction, an emerging contemporary research area of great importance to environmental toxicology, since it is becoming increasingly apparent that toxicants exert their biological actions by interfering with inter- and intra-cellular signaling pathways that affect gene expression and cellular function. The research objective of this program is to assist Florida A&M faculty in the development of contemporary concepts, approaches, and technologies for elucidating mechanisms associated with disruption of signal transduction pathways, second messengers, and effectors as a consequence of exposure to environmental agents. The primary objective of this program is to establish mentoring relationships, which will develop into collaborative interactions and will result in publication of manuscripts in high quality peer-reviewed journals and the funding of competitive peer-reviewed research grant applications. The specific objectives to be accomplished include assisting Florida A&M University faculty with 1) the development of specific objectives derived from a hypothesis-based concept which will result in an RO1-type grant submission, 2) the planning and execution of experiments designed to provide preliminary data in support of peer-reviewed grant applications, 3) in the use of contemporary molecular, cellular, or immunological cDNA array and RT-PCR approaches, 4) with guidance in the purchase of equipment and establishment of a core facility, 5) with a mentoring-intensive education/enrichment program, 6) with the production and submission of manuscripts to peer-review journals and grant applications, 7) through reviewing submitted manuscripts and grant proposals, 8) through attaining R01-like funding for the mentored faculty within the time frame of this grant, preferably within four years. External and Internal Advisory Boards, scheduled meetings and laboratory rotations, and specific objectives have been identified. Pilot projects have been established between Florida A&M University faculty in the College of Pharmacy and Pharmaceutical Sciences and FAMU Environmental Sciences Institute and faculty in the Institute of Chemical Toxicology and EHS Center. It is envisioned that through these interactions and objectives the research capacity of investigators at Florida A&M University will be enhanced.

描述（由申请人提供）： 佛罗里达农工大学 (FAMU) 的教职人员与教职人员合作 化学毒理学与环境健康科学研究所（EHS） 韦恩分子和细胞毒理学与人类应用中心 州立大学正在提议一项高级研究合作计划 基础环境健康科学。该计划将提供 指导和发展佛罗里达 A&M 教师所需的基础设施 现代概念在分子和细胞生物学及相关领域的应用 实验方法和技术，使这些研究人员能够 能够研究环境影响的分子机制 化学物质调节细胞和组织的反应。研究重点为 研究人员在这项倡议中研究的是信号转导，一种新兴的 环境毒理学非常重要的当代研究领域， 因为越来越明显的是，有毒物质发挥其作用 通过干扰细胞间和细胞内信号传导发挥生物作用 影响基因表达和细胞功能的途径。研究 该计划的目标是协助佛罗里达 A&M 教师开发 当代概念、方法和技术的阐释 与信号转导途径破坏相关的机制，第二 由于暴露于环境而产生的信使和效应器 代理。该计划的主要目标是建立指导 关系，这将发展为协作互动，并将 导致在高质量同行评审期刊上发表手稿 以及竞争性同行评审研究资助申请的资助。这 要实现的具体目标包括协助佛罗里达农工大学 大学教职人员具有 1) 制定源自的具体目标 一个基于假设的概念，将导致提交 RO1 型赠款， 2) 实验的规划和执行旨在提供初步的 支持同行评审拨款申请的数据，3) 使用 现代分子、细胞或免疫 cDNA 阵列和 RT-PCR 方法，4）指导购买设备和建立 核心设施，5) 具有指导密集型教育/强化计划， 6) 制作并向同行评审期刊提交稿件 和资助申请，7）通过审查提交的手稿和资助 提案，8) 通过为受指导的教师获得类似 R01 的资助 在这笔赠款的期限内，最好是四年内。 外部和内部顾问委员会、预定会议和实验室 轮换，并确定了具体目标。试点项目有 佛罗里达农工大学 (Florida A&M University) 学院的教师之间建立了 药学和药物科学以及 FAMU 环境科学研究所 以及化学毒理学研究所和EHS中心的教师。这是 设想通过这些相互作用和目标，研究 佛罗里达农工大学调查人员的能力将得到加强。