Advanced Research Cooperation In Environmental Health S*

描述(由申请人提供)： 佛罗里达农工大学(FAMU)与教职员工合作 在化学毒理学和环境健康科学研究所(EHS) 韦恩分子和细胞毒理学与人类应用中心 州立大学正在提出一项高级研究合作计划 基础环境健康科学。该计划将提供 指导和发展佛罗里达农工学院教师所需的基础设施 当代概念在分子和细胞生物学及相关领域的应用 实验方法和技术，使这些调查人员 能够深入研究环境保护的分子机制 化学物质调节细胞和组织的反应。的研究重点 研究人员在这一倡议中是信号转导，一种新兴的 对环境毒理学具有重要意义的当代研究领域 因为越来越明显的是，毒物发挥了他们的 干扰细胞内和细胞内信号的生物学行为 影响基因表达和细胞功能的途径。这项研究 该计划的目标是帮助佛罗里达农工学院发展 当代概念、方法和技术，用于阐明 与信号转导通路中断相关的机制，第二 作为暴露在环境中的结果的信使和效应者 探员们。该计划的主要目标是建立指导 关系，这将发展为协作互动，并将 在高质量同行评议期刊上发表手稿的结果 以及为竞争性同行评议的研究拨款申请提供资金。这个 要完成的具体目标包括协助佛罗里达A&M 大学教职员工1)从以下方面制定具体目标 一个基于假设的概念，它将导致RO1类型的拨款提交， 2)计划和执行旨在提供初步支持的实验 支持经同行审查的赠款申请的数据，3)使用 当代分子、细胞或免疫学基因芯片和RT-PCR 方法，4)在购买设备和建立 核心设施，5)有指导密集的教育/增收计划， 6)制作手稿并向同行评议期刊提交 和拨款申请，7)通过审阅提交的稿件和拨款 建议，通过为被指导的教职员工获得类似R01的资金 在这笔赠款的时间范围内，最好是在四年内。 外部和内部咨询委员会、预定会议和实验室 轮换，并确定了具体目标。试点项目有 在佛罗里达农工大学教职员工之间建立了 药学和药学与FAMU环境科学研究所 以及化学毒理学研究所和EHS中心的教职员工。它是 设想通过这些互动和目标，这项研究 佛罗里达农工大学的调查人员能力将得到增强。

DESCRIPTION (provided by applicant): Faculty members at Florida A&M University (FAMU), in partnership with faculty in the Institute of Chemical Toxicology and Environmental Health Science (EHS) Center in Molecular and Cellular Toxicology with Human Applications at Wayne State University are proposing an advanced research cooperation program in basic environmental health sciences. This program will provide the infrastructure required for mentoring and developing Florida A&M faculty in the use of contemporary concepts in molecular and cell biology and related experimental approaches and technologies such that these investigators will be able to pursue studies of the molecular mechanisms by which environmental chemicals modulate the response of cells and tissues. The research focus of investigators in this initiative is signal transduction, an emerging contemporary research area of great importance to environmental toxicology, since it is becoming increasingly apparent that toxicants exert their biological actions by interfering with inter- and intra-cellular signaling pathways that affect gene expression and cellular function. The research objective of this program is to assist Florida A&M faculty in the development of contemporary concepts, approaches, and technologies for elucidating mechanisms associated with disruption of signal transduction pathways, second messengers, and effectors as a consequence of exposure to environmental agents. The primary objective of this program is to establish mentoring relationships, which will develop into collaborative interactions and will result in publication of manuscripts in high quality peer-reviewed journals and the funding of competitive peer-reviewed research grant applications. The specific objectives to be accomplished include assisting Florida A&M University faculty with 1) the development of specific objectives derived from a hypothesis-based concept which will result in an RO1-type grant submission, 2) the planning and execution of experiments designed to provide preliminary data in support of peer-reviewed grant applications, 3) in the use of contemporary molecular, cellular, or immunological cDNA array and RT-PCR approaches, 4) with guidance in the purchase of equipment and establishment of a core facility, 5) with a mentoring-intensive education/enrichment program, 6) with the production and submission of manuscripts to peer-review journals and grant applications, 7) through reviewing submitted manuscripts and grant proposals, 8) through attaining R01-like funding for the mentored faculty within the time frame of this grant, preferably within four years. External and Internal Advisory Boards, scheduled meetings and laboratory rotations, and specific objectives have been identified. Pilot projects have been established between Florida A&M University faculty in the College of Pharmacy and Pharmaceutical Sciences and FAMU Environmental Sciences Institute and faculty in the Institute of Chemical Toxicology and EHS Center. It is envisioned that through these interactions and objectives the research capacity of investigators at Florida A&M University will be enhanced.