Advanced Research Cooperation In Environmental Health S*

描述（由申请人提供）： 佛罗里达A & M大学（FAMU）的教师，与教师合作 化学毒理学和环境健康科学研究所（EHS） 韦恩的分子和细胞毒理学与人类应用中心 州立大学提出了一个先进的研究合作计划， 基础环境卫生科学。该计划将提供 指导和发展佛罗里达A & M教师所需的基础设施， 现代概念在分子和细胞生物学及相关领域的应用 实验方法和技术，这些研究人员将 能够进行分子机制的研究，环境 化学物质调节细胞和组织的反应。的研究热点 研究人员在这一倡议是信号转导，一个新兴的 当代环境毒理学的重要研究领域， 因为越来越明显的是， 通过干扰细胞间和细胞内信号传导的生物学作用 影响基因表达和细胞功能的途径。研究 该计划的目标是协助佛罗里达A & M教师的发展 当代的概念，方法和技术，以阐明 与信号转导途径中断相关的机制，第二 信使和效应器作为暴露于环境的结果， 剂.该计划的主要目标是建立指导 关系，这将发展成为合作的互动，并将 在高质量的同行评审期刊上发表手稿 以及资助竞争性的同行评审研究资助申请。的 具体目标包括协助佛罗里达A & M 大学教师与1）发展的具体目标，从 一个基于假设的概念，将导致一个RO1型赠款提交， 2)计划和执行旨在提供初步 支持同行评审赠款申请的数据，3）使用 当代分子、细胞或免疫学cDNA阵列和RT-PCR 方法，4）在购买设备和建立 一个核心设施，5）有一个辅导密集型教育/丰富计划， 6)制作和向同行评审期刊提交手稿 7）通过审查提交的手稿和赠款申请， 建议，8）通过获得R01类资金的指导教师 最好是在四年之内。 外部和内部咨询委员会、预定会议和实验室 已经确定了具体目标。试点项目 佛罗里达A & M大学教师之间建立了 药学和制药科学与FAMU环境科学研究所 以及化学毒理学研究所和EHS中心的教员。是 设想通过这些相互作用和目标， 佛罗里达A & M大学的调查能力将得到加强。

DESCRIPTION (provided by applicant): Faculty members at Florida A&M University (FAMU), in partnership with faculty in the Institute of Chemical Toxicology and Environmental Health Science (EHS) Center in Molecular and Cellular Toxicology with Human Applications at Wayne State University are proposing an advanced research cooperation program in basic environmental health sciences. This program will provide the infrastructure required for mentoring and developing Florida A&M faculty in the use of contemporary concepts in molecular and cell biology and related experimental approaches and technologies such that these investigators will be able to pursue studies of the molecular mechanisms by which environmental chemicals modulate the response of cells and tissues. The research focus of investigators in this initiative is signal transduction, an emerging contemporary research area of great importance to environmental toxicology, since it is becoming increasingly apparent that toxicants exert their biological actions by interfering with inter- and intra-cellular signaling pathways that affect gene expression and cellular function. The research objective of this program is to assist Florida A&M faculty in the development of contemporary concepts, approaches, and technologies for elucidating mechanisms associated with disruption of signal transduction pathways, second messengers, and effectors as a consequence of exposure to environmental agents. The primary objective of this program is to establish mentoring relationships, which will develop into collaborative interactions and will result in publication of manuscripts in high quality peer-reviewed journals and the funding of competitive peer-reviewed research grant applications. The specific objectives to be accomplished include assisting Florida A&M University faculty with 1) the development of specific objectives derived from a hypothesis-based concept which will result in an RO1-type grant submission, 2) the planning and execution of experiments designed to provide preliminary data in support of peer-reviewed grant applications, 3) in the use of contemporary molecular, cellular, or immunological cDNA array and RT-PCR approaches, 4) with guidance in the purchase of equipment and establishment of a core facility, 5) with a mentoring-intensive education/enrichment program, 6) with the production and submission of manuscripts to peer-review journals and grant applications, 7) through reviewing submitted manuscripts and grant proposals, 8) through attaining R01-like funding for the mentored faculty within the time frame of this grant, preferably within four years. External and Internal Advisory Boards, scheduled meetings and laboratory rotations, and specific objectives have been identified. Pilot projects have been established between Florida A&M University faculty in the College of Pharmacy and Pharmaceutical Sciences and FAMU Environmental Sciences Institute and faculty in the Institute of Chemical Toxicology and EHS Center. It is envisioned that through these interactions and objectives the research capacity of investigators at Florida A&M University will be enhanced.