CELLULAR & MOLECULAR TOXICOLOGY OF BUTADIENE

蜂窝网络

• 批准号: 6644896
• 负责人: PERPETUA M MUGANDA
• 金额: $ 101.23万
• 依托单位: SOUTHERN UNIV A&M COL BATON ROUGE
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-08-15 至 2007-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6644896
• 关键词: cooperative study; diene; environmental toxicology; minority institution research support; mutagens

A multi-disciplinary research and developmental collaborative program project is proposed between faculty at Southern University at Baton Rouge (SUBR) and faculty at the NIEHS Center for Environmental Toxicology, The University of Texas Medical Branch at Galveston (UTMB). The overall goal of this partnership is to foster long-term formal collaborations between the two institutions for the purposes of increasing scientific productivity and establishing a group of Souther University investigators who cam compete successfully for NIH R01 funding in environmental health sciences. In order to accomplish this goal, SUBR is requesting five-year funding to support the following initiatives: (1) the development of a multi-disciplinary collaborative research program focused on understanding the molecular, cellular and organismal mechanisms of butadiene toxicity. Butadiene, an environmental chemical, is a know mutagen and probable human carcinogen, and is one of the most common pollutants in petrochemical industrial areas, some of which are located in both Louisiana and Texas. The three pilot projects proposed by investigators on the SUBR campus will be directly related to the three research projected proposed by scientists at UTMB. The planned research collaborations will allow the exchange of samples and ideas between SUBR and UTMB investigators, facilitating the efficient acquisition and correlation of research information. (2) The enhancement of the feasibility and efficiency of attaining research productivity by sustaining and developing facility core units that will provide equipment or service to the proposed projects. (3) The development of an administrative and planning core unit that will be responsible for managing the program, as well as planning developmental activities needed to facilitate the acquisition of R01 grants by SUBR investigators. (4) Effectively increase the number of NIH R01- level scientists at Southern University, through the recruitment of new faculty with a strong record of obtaining research project grants in environmental health sciences. The overall outcome of this collaborative program will be increased scientific development, productivity, and ability of SUBR investigators to successfully compete for NIH R01 funding in environmental health sciences.

南方大学巴吞鲁日（SUBR）的教师和德克萨斯大学加尔维斯顿医学分支（UTMB）的NIEHS环境毒理学中心的教师之间提出了一个多学科的研究和发展合作计划项目。这种伙伴关系的总体目标是促进两个机构之间的长期正式合作，以提高科学生产力，并建立一个南方大学研究人员小组，他们可以成功地竞争NIH R01环境健康科学资金。为了实现这一目标，SUBR正在申请五年期资金，以支持以下举措：（1）开发一个多学科合作研究计划，重点是了解丁二烯毒性的分子，细胞和生物机制。丁醇是一种环境化学品，是已知的诱变剂和可能的人类致癌物，是石油化工工业区最常见的污染物之一，其中一些位于路易斯安那州和德克萨斯州。研究人员在SUBR校园提出的三个试点项目将与UTMB科学家提出的三项研究计划直接相关。计划中的研究合作将允许SUBR和UTMB研究人员之间交换样本和想法，促进研究信息的有效获取和关联。(2)通过维持和发展为拟议项目提供设备或服务的设施核心单元，提高实现研究生产力的可行性和效率。(3)发展一个行政和规划核心单位，负责管理该计划，以及规划促进SUBR调查人员获得R01赠款所需的发展活动。(4)有效地增加在南方大学的NIH R01级科学家的数量，通过招聘新的教师与获得环境健康科学研究项目赠款的良好记录。这项合作计划的总体成果将提高科学发展，生产力和SUBR研究人员成功竞争NIH R01环境健康科学资金的能力。

项目成果

Potential Benefits of Peroxynitrite.

• DOI: 10.2174/1874143600802010031
• 发表时间: 2008-06
• 期刊: The open pharmacology journal
• 作者: B. Nossaman;P. Kadowitz

Diepoxybutane activates the mitochondrial apoptotic pathway and mediates apoptosis in human lymphoblasts through oxidative stress.

二环氧丁烷激活线粒体凋亡途径并通过氧化应激介导人淋巴母细胞凋亡。

• DOI: 10.1016/j.tiv.2007.06.007
• 发表时间: 2007
• 期刊: Toxicology in vitro : an international journal published in association with BIBRA
• 作者: Yadavilli,Sridevi;Martinez-Ceballos,Eduardo;Snowden-Aikens,Janana;Hurst,Angela;Joseph,Tranole;Albrecht,Thomas;Muganda,PerpetuaM
• 通讯作者: Muganda,PerpetuaM