CELLULAR & MOLECULAR TOXICOLOGY OF BUTADIENE

巴吞鲁日南方大学(SUBR)的教职员工和德克萨斯大学加尔维斯顿分校(UTMB)NIEHS环境毒理学中心的教职员工提出了一个多学科研究和开发合作项目。这一伙伴关系的总体目标是促进两个机构之间的长期正式合作，目的是提高科学生产率，并建立一组能够成功竞争NIH R01环境健康科学资金的南方大学研究人员。为了实现这一目标，SUBR正在申请为期五年的资金，以支持以下举措：(1)制定一项多学科合作研究计划，重点了解丁二烯毒性的分子、细胞和组织机制。丁二烯是一种环境化学品，是已知的诱变剂和可能的人类致癌物，是石化工业区最常见的污染物之一，其中一些位于路易斯安那州和德克萨斯州。调查人员提出的三个试点项目将与UTMB的科学家们提出的三项研究直接相关。计划中的研究合作将允许研究小组和UTMB调查人员之间交换样本和想法，促进研究信息的有效获取和相互关联。(2)通过维持和发展将为拟议项目提供设备或服务的设施核心单位，提高获得研究生产力的可行性和效率。(3)建立一个行政和规划核心单位，负责管理该计划，并规划必要的发展活动，以促进SUBR调查人员获得R01赠款。(4)通过招聘在获得环境健康科学研究项目拨款方面有良好记录的新教员，有效增加南方大学NIH R01级科学家的数量。这一合作计划的总体结果将是提高科学发展、生产率和SUBR研究人员成功竞争环境健康科学领域NIH R01资金的能力。

A multi-disciplinary research and developmental collaborative program project is proposed between faculty at Southern University at Baton Rouge (SUBR) and faculty at the NIEHS Center for Environmental Toxicology, The University of Texas Medical Branch at Galveston (UTMB). The overall goal of this partnership is to foster long-term formal collaborations between the two institutions for the purposes of increasing scientific productivity and establishing a group of Souther University investigators who cam compete successfully for NIH R01 funding in environmental health sciences. In order to accomplish this goal, SUBR is requesting five-year funding to support the following initiatives: (1) the development of a multi-disciplinary collaborative research program focused on understanding the molecular, cellular and organismal mechanisms of butadiene toxicity. Butadiene, an environmental chemical, is a know mutagen and probable human carcinogen, and is one of the most common pollutants in petrochemical industrial areas, some of which are located in both Louisiana and Texas. The three pilot projects proposed by investigators on the SUBR campus will be directly related to the three research projected proposed by scientists at UTMB. The planned research collaborations will allow the exchange of samples and ideas between SUBR and UTMB investigators, facilitating the efficient acquisition and correlation of research information. (2) The enhancement of the feasibility and efficiency of attaining research productivity by sustaining and developing facility core units that will provide equipment or service to the proposed projects. (3) The development of an administrative and planning core unit that will be responsible for managing the program, as well as planning developmental activities needed to facilitate the acquisition of R01 grants by SUBR investigators. (4) Effectively increase the number of NIH R01- level scientists at Southern University, through the recruitment of new faculty with a strong record of obtaining research project grants in environmental health sciences. The overall outcome of this collaborative program will be increased scientific development, productivity, and ability of SUBR investigators to successfully compete for NIH R01 funding in environmental health sciences.