Diene regenerative Diels-Alder reactions to access chemical scaffolds

二烯再生狄尔斯-阿尔德反应获得化学支架

• 批准号: DP170101652
• 负责人: Prof Jonathan Morris
• 金额: $ 21.29万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-09-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP170101652
• 关键词: Diene; regenerative; Diels; Alder; reactions

This project aims to develop methods and strategies that allow rapid access to biologically active chemical scaffolds based on natural products. Natural products and their analogues are vital starting points for drug discovery as they provide unique chemical diversity. Without efficient methods for their production, it is not possible to exploit this diversity. This project will develop an efficient, modular strategy that will allow the preparation of a wide range of chemicals in a timely manner. Restoring access to potent biologically active materials is expected to generate chemical probes and lead to molecules that could have biomedical value.

该项目旨在开发方法和策略，允许快速获得基于天然产品的生物活性化学支架。天然产物及其类似物是药物发现的重要起点，因为它们提供了独特的化学多样性。如果没有有效的生产方法，就不可能利用这种多样性。该项目将制定一项有效的模块化战略，以便及时制备各种化学品。恢复获得有效的生物活性材料有望产生化学探针，并导致可能具有生物医学价值的分子。