Diene regenerative Diels-Alder reactions to access chemical scaffolds

该项目旨在开发基于天然产物的生物活性化学支架的快速获取方法和策略。天然产物及其类似物是药物发现的重要起点，因为它们提供了独特的化学多样性。如果没有有效的生产方法，就不可能利用这种多样性。该项目将制定有效的模块化战略，以便及时制备各种化学品。恢复对强效生物活性材料的获取有望产生化学探针，并导致可能具有生物医学价值的分子。

This project aims to develop methods and strategies that allow rapid access to biologically active chemical scaffolds based on natural products. Natural products and their analogues are vital starting points for drug discovery as they provide unique chemical diversity. Without efficient methods for their production, it is not possible to exploit this diversity. This project will develop an efficient, modular strategy that will allow the preparation of a wide range of chemicals in a timely manner. Restoring access to potent biologically active materials is expected to generate chemical probes and lead to molecules that could have biomedical value.