DOSE-RESPONSE TO EXERCISE IN WOMEN AGED 45-75 YEARS

45-75 岁女性运动的剂量反应

• 批准号: 6696270
• 负责人: STEVEN N. BLAIR
• 金额: $ 71.17万
• 依托单位: COOPER INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-01-15 至 2005-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6696270
• 关键词: blood glucose; blood lipid; blood pressure; body composition; cardiovascular disorder; cardiovascular disorder therapy; cardiovascular function; clinical research; disease /disorder proneness /risk; exercise; female; human middle age (35-64); human old age (65+); human subject; human therapy evaluation; insulin; obesity; outcomes research; oxygen consumption; postmenopause; quality of life; respiratory function; social psychology; women' s health

The primary goal of the Dose-Response to Exercise in Women Aged 45-75 Years (DREW) is to investigate the effects of different amounts of exercise on both cardiorespiratory fitness and risk factors for cardiovascular disease. Participants will be sedentary, overweight or obese, postmenopausal women who have high normal blood pressure or Stage I hypertension, and thus are at moderately high risk for cardiovascular disease. A total of 450 women (35 percent will be from minority groups) will be randomly assigned to a control group (N=100) or to 1 of 3 exercise groups (N=150 for the lowest exercise dose and 100 each in the two highest exercise groups). Women assigned to the exercise groups will exercise for 6 months at energy expenditures of 4, 8, or 12 kcal/kg per week. These exercises doses represent the consensus public health recommendation for physical activity from recently published guidelines from the U.S. Public Health Service, American Heart Association, and the American College of Sports Medicine (8 kcal/kg per week) and at doses 50 percent below (4 kcal/kg per week) 50 percent above (12 kcal/kg per week) the consensus dose. All women will exercise at 50 percent of VO2 max. The exercise sessions will take place in the laboratory, with individual supervision of each session and strict control of frequency, duration, and intensity. This will provide thorough documentation of the exact amount of exercise completed. Primary outcome measures are VO2 max and resting systolic blood pressure. Other cardiovascular disease risk factors, psychosocial variables, health-related quality of life, body composition, and fat distribution are secondary outcomes. Other secondary analyses will include a focus on the extent to which observed dose-response effects are modified by baseline levels of fitness, ethnicity, risk factors, or age. Assessments will take place at baseline and 6 months. The research will provide information about (1) patterns of change in outcomes produced by each of several exercise doses, (2) whether performing exercise at less than the current consensus dose has any benefit, (3) whether performing more exercise than the consensus dose has greater (or proportionally greater) health benefits, and (4) the characteristics of sedentary women who are most likely to benefit from various exercise doses.

老年女性运动剂量反应的主要目标 45-75 年 (DREW) 旨在研究不同数量的效果 运动对心肺健康和心血管危险因素的影响 疾病。参与者将久坐、超重或肥胖、绝经后 患有正常高血压或 I 期高血压的女性，因此 患有心血管疾病的中高风险。共有 450 名女性（35 百分比将来自少数群体）将被随机分配给对照组 组 (N=100) 或 3 个运动组中的 1 个（N=150 为最低运动剂量 两个最高运动组各 100 次）。妇女被分配到 运动组将以 4、8 或 4 的能量消耗进行 6 个月的运动 每周 12 大卡/公斤。这些练习剂量代表了公众的共识 最近发布的指南中关于身体活动的健康建议 来自美国公共卫生服务部、美国心脏协会和 美国运动医学学院（每周 8 kcal/kg），剂量 50 低于（每周 4 kcal/kg）的百分比 高于（每周 12 kcal/kg）的 50% 共识剂量。所有女性都会以最大摄氧量的 50% 进行锻炼。练习 会议将在实验室进行，每个人都有单独的监督 严格控制频率、持续时间和强度。这将 提供完整的记录，记录已完成的确切运动量。 主要结果指标是最大摄氧量和静息收缩压。其他 心血管疾病危险因素、心理社会变量、健康相关 生活质量、身体成分和脂肪分布是次要结果。 其他二次分析将包括关注观察到的程度 剂量反应效应会根据健康水平、种族、 危险因素，或年龄。评估将在基线和 6 个月后进行。这 研究将提供有关 (1) 结果变化模式的信息 几个运动剂量中的每一个产生的，（2）是否进行运动 低于当前共识剂量有任何益处，（3）是否执行 更多的运动量比共识剂量更大（或按比例更大） 健康益处，以及（4）久坐女性的特征 可能从不同的运动剂量中受益。