Genetic anthropology of the blood lipid level

血脂水平的遗传人类学

• 批准号: 21687021
• 负责人: NAKAYAMA Kazuhiro
• 金额: $ 7.07万
• 依托单位: Jichi Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (A)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21687021/
• 关键词: 遺伝子; 多型; 人類; 進化; 中性脂肪; コレステロール; 人類学; 遺伝学; 脂質; ゲノム

To elucidate anthropological significance of genetic variation for blood lipid level in humans, over 20,000 individuals from 5 Asian and Oceanian groups were investigated for common and rare variants of lipid associated genes. 1) Effects of FADS (fatty acid desaturase) gene variants on blood lipid level were dramatically varied between Mongolians and Japanese. Differences in dietary intake of unsaturated fatty acid would explain the variation in phenotypic effects of the FADS gene variants. 2) Anti-hypertriglyceridemic MLXIPL Gln241His variant was found with high frequencies in central Asians who can be traced back to nomadic pastoralists. Gln241His variant might have been significant for utilization of carbohydrates and fats in nomadic pastoralists. 3) Resequencing of Scavenger receptor class B gene family revealed excess of rare variants among Thai individuals. This suggested a possible link between genetic variation of lipid metabolism and malaria resistance. 4) Additionally, the present study showed that in an association study of blood lipid level, adjustment for visceral fat accumulation can improve sensitivity of detecting effects of genetic variants.

为了阐明遗传变异对人类血脂水平的人类学意义，对来自亚洲和大洋洲5个群体的20，000多名个体进行了血脂相关基因的常见和罕见变异的调查。1)脂肪酸去饱和酶（FADS）基因变异对血脂水平的影响在蒙古族和日本人之间存在显著差异。膳食摄入不饱和脂肪酸的差异可以解释FADS基因变异体表型效应的差异。2)抗高血糖MLXIPL Gln241His变异体在中亚人中发现的频率很高，可以追溯到游牧民族。Gln241His变异体可能对游牧牧民利用碳水化合物和脂肪具有重要意义。3)对清道夫受体B类基因家族的重新测序显示泰国个体中存在过多的罕见变异。这表明脂质代谢的遗传变异与疟疾抗性之间可能存在联系。4)此外，本研究表明，在血脂水平的关联研究中，调整内脏脂肪堆积可以提高检测遗传变异影响的灵敏度。

项目成果

A single nucleotide polymorphism in the FADS1/FADS2 gene is associated with plasma lipid profiles in two genetically similar Asian ethnic groups with distinctive differences in lifestyle

• DOI: 10.1007/s00439-010-0815-6
• 发表时间: 2010-06-01
• 期刊: HUMAN GENETICS
• 影响因子: 5.3
• 作者: Nakayama, Kazuhiro;Bayasgalan, Tumenbayer;Iwamoto, Sadahiko
• 通讯作者: Iwamoto, Sadahiko

Variations in the coding region of the agouti signaling protein gene do not explain agouti/non-agouti phenotypes in macayues.

刺豚鼠信号蛋白基因编码区的变异不能解释玛卡尤斯的刺豚鼠/非刺豚鼠表型。

• 发表时间: 2010
• 期刊: Journal Mammalian Evolution
• 作者: Horibe;T.;Ito;M. and Yamada;K.;Igaki T;Nakayama K
• 通讯作者: Nakayama K

アジア人集団におけるFADS1/FADS2およびABCG5/ABCG8遺伝子多型の血清脂質量への寄与の検討

检查 FADS1/FADS2 和 ABCG5/ABCG8 基因多态性对亚洲人群血脂水平的影响

• 发表时间: 2009
• 作者: Ochiai;M.;Takagaki;N.;Maesaka;M.;Yamada;K.;小川歩美;中山一大;中山一大;中山一大;中山一大;中山一大
• 通讯作者: 中山一大

Anthropological insights into the genetic diversity of MLXIPL (2010)

对 MLXIPL 遗传多样性的人类学见解 (2010)

• 发表时间: 2010
• 期刊: DNA polymorphism
• 作者: Nakayama K;Yanagisawa Y;Gotoh T;Yamanaka K;Ogawa Y;Iwamoto S;Mukhtulga L;Koda Y;Ishida T;Kagawa Y
• 通讯作者: Kagawa Y

撓骨動脈トノメトリ波形解析から得られる血管年齢指標の検討

通过桡动脉张力测量波形分析获得的血管年龄指数的检查

• 发表时间: 2010
• 作者: 河村耕史、岩田光、山田邦夫、松本省吾、福井博一、Jeauffre;J.、Thouroude;T.;宮下洋
• 通讯作者: 宮下洋