The development of novel technologies for the design of next generation skin products

开发下一代皮肤产品设计的新技术

• 批准号: 2376658
• 金额: --
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2376658
• 关键词: development; novel; technologies; design; next

In order to design a new generation of skin-based products for the personal care sector it is important to understand the molecular interactions that occur between biobased compounds (including those derived from plants) with the different molecular assemblies present with skin. Platform technologies capable of facilitating such measurements would address a long-standing technological bottleneck related to the need to establish in-vitro screening methodologies related to anti-inflammatory responses and anti-ageing. Using cutting edge additive manufacturing approaches coupled with microfluidics this project aims to design and exploit novel skin-on-a-chip systems. By exploiting innovation in the physical sciences these model microphysiological environments will provide robust, user-defined, reproducible systems that can be coupled with novel spectroscopies and chromatographic approaches that can used to profile active compounds from plants in high-throughput.

为了设计用于个人护理部门的新一代基于皮肤的产品，重要的是理解生物基化合物（包括源自植物的那些）与皮肤中存在的不同分子组装体之间发生的分子相互作用。能够促进此类测量的平台技术将解决一个长期存在的技术瓶颈，即需要建立与抗炎反应和抗衰老有关的体外筛选方法。该项目使用尖端的增材制造方法与微流体技术相结合，旨在设计和开发新型的芯片皮肤系统。通过利用物理科学中的创新，这些模型微生理环境将提供强大的，用户定义的，可重复的系统，可以与新的光谱和色谱方法相结合，可以用于高通量地分析植物中的活性化合物。