CLINICAL RESEARCH SERVICES

虽然PET设施自1992年就已存在，但在CCSG申请中首次提议将其作为UPCI共享设施。占地约12,000平方英尺。英国《金融时报》在UPMC长老会医院内，该设施配备了一个医疗回旋加速器，一个大型放射化学实验室，三个患者扫描套房，住院和门诊准备室，动物实验和代谢物分析实验室，以及PET办公室 研究人员和工作人员。 在体内，PET可以提供关于癌症特定分子途径的独特信息。它通过提供有关生物过程和体内特定细胞途径的独特信息，已成为分子成像方法的宝贵工具。NCI已经认识到，与癌症相关的分子成像策略的发展及其临床应用是未来的一个重要挑战。 该设施的具体目标是(1)提供可获得的、全面的和最先进的PET成像服务，以支持基础和临床UPCI研究计划，(2)在实验设计、开发、验证和实施方法以及研究数据的解释方面提供指导。PET设施有用于人体PET成像的仪器(包括3台人体PET断层扫描仪和1台CPS PET/CT扫描仪)，小 动物PET成像(包括协和微系统公司的Micro-PET P4扫描仪)和一个放射化学实验室(包括3个CapINTEC热室和4个CapINTEC“迷你洞穴”)，用于开发癌症相关成像的新示踪剂。它在希尔曼癌症中心和UPMC长老会医院都有一个临床PET中心，2001年在那里进行了1667项研究，2002年进行了2400项研究，预计2003年的研究数量将超过3000项。该设施还运营着一个广泛的计算机和数据处理网络。此外，它还指导学员。 该设施有很大的潜力支持UPCI的研究项目，包括在PET/CT辅助下的放射治疗计划，以及通过PET或PET和CT的组合对肿瘤模型进行小动物成像，随后将有希望的结果转化为癌症诊断和治疗反应的非侵入性监测的临床应用。

Although in existence since 1992, the PET Facility is being proposed as a UPCI Shared Facility for the first time in the CCSG application. Occupying approximately 12,000 sq. ft. within the UPMC Presbytarian Hospital, the Facility is well equipped with a medical cyclotron, a large radiochemistry laboratory, and three patient scanning suites, inpatient and outpatient preparation rooms, laboratories for animal experimentation and metabolite analysis, and offices for PET research faculty and staff. PET can provide unique in vivo information about specific molecular pathways in cancer. It has become a valuable tool for molecular imaging approaches by providing unique information about biological processes and specific cellular pathways in vivo. The development of molecular imaging strategies related to cancer and their translation into clinical application has been recognized by the NCI as an important challenge for the future. The specific aims of the Facility are (1) to provide accessible, comprehensive, and state-of-the-art PET imaging services in support of basic and clinical UPCI research program, and (2) to provide guidance in experimental design, development, validation and implementation of methodology and the interpretation of study data. The PET Facility has instrumentation for human PET imaging (including 3 human PET tomographs and a CPS PET/CT scanner), small animal PET imaging (including a Concorde Micorsystems micro-PET P4 scanner), and a radiochemistry lab (including 3 Capintec hot cells and 4 Capintec 'mini-caves') for development of new tracers for cancer-related imaging. It also has a clinical PET center at both the Hillman cancer Center and UPMC Presbyterian, where 1,667 studies were performed in 2001, 2,400 in 2002 and the projected volume for 2003 is over 3,000. The Facility also operates an extensive computer and data processing network. In addition, it also mentors trainees. The Facility has much potential for support of UPCI's research programs, including in radiation treatment planning with the aid of PET/CT, and small animal imaging of tumor models by PET or a combination of PET and CT, with subsequent translation of promising results into clinical applications for cancer diagnosis and for noninvasive monitoring of response to therapy.