CLINICAL RESEARCH SERVICES

临床研究服务

• 批准号: 6989593
• 负责人: RONALD B HERBERMAN
• 金额: $ 5.46万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-22 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6989593
• 关键词: biomedical facility; computer data analysis; molecular oncology; neoplasm /cancer; neoplasm /cancer radiation therapy; neoplasm /cancer radiodiagnosis; particle accelerators; positron emission tomography; radiochemistry

Although in existence since 1992, the PET Facility is being proposed as a UPCI Shared Facility for the first time in the CCSG application. Occupying approximately 12,000 sq. ft. within the UPMC Presbytarian Hospital, the Facility is well equipped with a medical cyclotron, a large radiochemistry laboratory, and three patient scanning suites, inpatient and outpatient preparation rooms, laboratories for animal experimentation and metabolite analysis, and offices for PET research faculty and staff. PET can provide unique in vivo information about specific molecular pathways in cancer. It has become a valuable tool for molecular imaging approaches by providing unique information about biological processes and specific cellular pathways in vivo. The development of molecular imaging strategies related to cancer and their translation into clinical application has been recognized by the NCI as an important challenge for the future. The specific aims of the Facility are (1) to provide accessible, comprehensive, and state-of-the-art PET imaging services in support of basic and clinical UPCI research program, and (2) to provide guidance in experimental design, development, validation and implementation of methodology and the interpretation of study data. The PET Facility has instrumentation for human PET imaging (including 3 human PET tomographs and a CPS PET/CT scanner), small animal PET imaging (including a Concorde Micorsystems micro-PET P4 scanner), and a radiochemistry lab (including 3 Capintec hot cells and 4 Capintec 'mini-caves') for development of new tracers for cancer-related imaging. It also has a clinical PET center at both the Hillman cancer Center and UPMC Presbyterian, where 1,667 studies were performed in 2001, 2,400 in 2002 and the projected volume for 2003 is over 3,000. The Facility also operates an extensive computer and data processing network. In addition, it also mentors trainees. The Facility has much potential for support of UPCI's research programs, including in radiation treatment planning with the aid of PET/CT, and small animal imaging of tumor models by PET or a combination of PET and CT, with subsequent translation of promising results into clinical applications for cancer diagnosis and for noninvasive monitoring of response to therapy.

虽然自1992年以来就存在PET设施，但在CCSG申请中首次提出将其作为UPCI共享设施。占地约12，000平方米。英尺在UPMC长老会医院内，该设施配备了一台医用回旋加速器、一个大型放射化学实验室、三个病人扫描室、住院病人和门诊病人准备室、动物实验和代谢物分析实验室以及PET办公室 研究人员和工作人员。 PET可以提供关于癌症中特定分子途径的独特体内信息。它已成为一个有价值的工具，分子成像方法，提供独特的信息，生物过程和特定的细胞途径在体内。与癌症相关的分子成像策略的发展及其转化为临床应用已被NCI视为未来的重要挑战。 该机构的具体目标是（1）提供可访问的、全面的和最先进的PET成像服务，以支持基础和临床UPCI研究项目，以及（2）为实验设计、开发、验证和方法学实施以及研究数据解释提供指导。PET设施具有用于人体PET成像的仪器（包括3台人体PET断层扫描仪和一台CPS PET/CT扫描仪）、小型 动物PET成像（包括Concorde Micorsystems micro-PET P4扫描仪）和放射化学实验室（包括3个Capintec热室和4个Capintec“迷你洞穴”），用于开发癌症相关成像的新示踪剂。它还在希尔曼癌症中心和UPMC长老会医院设有临床PET中心，2001年进行了1，667项研究，2002年进行了2，400项研究，预计2003年将超过3，000项。该设施还拥有一个广泛的计算机和数据处理网络。此外，它还指导受训人员。 该设施有很大的潜力支持UPCI的研究计划，包括在PET/CT的帮助下进行放射治疗计划，通过PET或PET和CT的组合对肿瘤模型进行小动物成像，随后将有希望的结果转化为癌症诊断和治疗反应的非侵入性监测的临床应用。