CORE--BIOSTATISTICS

梅奥临床癌症中心的生物统计共享资源(MCCC)与MCCC的研究人员进行了30多年的专业统计合作。该资源的目的是提供统计和生物数学合作，以开发和开展由MCCC研究人员产生的同行评议的癌症研究。这项研究的范围从长椅到床边再到人群，涵盖了基础科学、临床试验、流行病学研究和其他转化和教育研究。CCSG向资源提供的资金的主要用途是支持在试点项目上的统计和数学合作，帮助调查人员制定获得批准的研究项目，这些项目没有以其他方式获得资助，但导致外部 资金，并支持在MCCC批准的项目上进行统计合作的意外需求。在生物统计共享资源的30年历史中，该组织在MCCC不断扩大的研究活动的推动下，经历了自然和刻意的演变和扩张。 生物统计共享资源将多个重点领域(团队)捆绑在一起，形成一个组织良好、高效的核心。它们是：(I)一个临床试验小组，负责癌症临床试验、相关的转化研究、介入性心理社会研究和成像，以及患者和公共教育研究项目；(Ii)一个人口科学小组，负责为包括遗传和分子流行病学在内的癌症观察性研究提供统计协作和数据管理支持；(Iii)一个生活质量小组，负责为正在调查临床和心理社会干预对癌症患者、家庭、照顾者和其他人的影响的MCCC调查人员提供一般和具体的建议、测量工具和分析；以及(Iv)一个生物数学小组，负责 提供成像、数据处理和分析、数学建模(例如肿瘤生长)以及一般数学或算法问题等数学方面的协作专业知识。这些小组高效地合作，为所有三个MCCC校区的梅奥诊所癌症中心的研究人员提供统计和生物数学合作。

The Biostatistics Shared Resource of the Mayo Clinic Cancer Center (MCCC) has provided expert statistical collaboration with MCCC investigators for over 30 years. The purpose of the resource is to provide statistical and biomathematical collaboration for the development and conduct of peer-reviewed cancer research generated by investigators in the MCCC. This research ranges from the bench to the bedside to the population, and encompasses basic science, clinical trials, epidemiologic research, and other translational and educational research. The primary usage of the funds provided to the resource by the CCSG is to support statistical and mathematical collaboration on pilot projects, for assistance to investigators in developing approved research projects not otherwise funded but leading towards external funding, and to support unanticipated needs for statistical collaboration on MCCC approved projects. Over the 30 year history of the Biostatistics Shared Resource, the group has undergone a natural and deliberate evolution and expansion, spurred by the expanding research activities of the MCCC. The Biostatistics Shared Resource has multiple focus areas (teams) tied together into a well-organized, efficient core. These are: (I) a Clinical Trials team responsible for cancer clinical trials, associated translational research, interventional psychosocial research, and imaging, together with patient and public education research projects, (II) a Population Science team responsible for providing statistical collaboration and data management support for cancer observational studies, including genetic and molecular epidemiology, (III) a Quality of Life team responsible for providing general and specific advice, measurement tools, and analysis for MCCC investigators who are investigating the impact of clinical and psychosocial interventions on cancer patients, families, caregivers, and others, and (IV) a Biomathematics team that provides collaborative expertise in the mathematical aspects of imaging, data processing and analysis, mathematical modeling (e.g. of tumor growth), and general mathematical or algorithmic issues. These groups work efficiently and effectively together to provide statistical and biomathematical collaboration to Mayo Clinic Cancer Center investigators across all three MCCC campuses.