Biostatics

生物静力学

• 批准号: 7945078
• 负责人: DANIEL J. SARGENT
• 金额: $ 56.94万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-17 至 2014-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7945078
• 关键词: Address; Adverse event; American Association of Cancer Research; American Society of Clinical Oncology; American Society of Hematology; Area; Basic Science; Bibliography; Biostatistics Shared Resource; Cancer Center Support Grant; Cancer Patient; Case-Control Studies; Characteristics; Clinical; Clinical Data Update System; Clinical Research; Clinical Trials; Clinical Trials Data Monitoring Committees; Cohort Studies; Collaborations; Collection; Complex; Comprehensive Cancer Center; Conduct Clinical Trials; Data Analyses; Data Collection; Data Element; Data Quality; Data Set; Databases; Development; Disease; Doctor of Philosophy; Elements; Eligibility Determination; Ensure; Epidemiologic Studies; Epidemiologist; Evolution; Faculty; Family; Family Caregiver; Funding; Genetic; Genomics; Goals; Grant; Housing; Human Resources; Image; Individual; Intervention; Laboratories; Lead; Learning; Life; Link; Malignant Neoplasms; Manuscripts; Mayo Clinic Cancer Center; Measurement; Molecular Epidemiology; Monitor; Observational Study; Outcome; Patients; Peer Review; Phase; Physicians; Pilot Projects; Policies; Population Sciences; Principal Investigator; Procedures; Process; Proteomics; Protocols documentation; Publications; Quality Control; Quality of life; Recording of previous events; Reporting; Research; Research Activity; Research Personnel; Research Project Grants; Resolution; Resource Sharing; Resources; SKIL gene; Sample Size; Sampling; Scientist; Services; Specialist; Specimen; Statistical Methods; Surveys; System; Time; Translational Research; United States National Institutes of Health; Work; Writing; anticancer research; biomathematics; cohort; computerized data processing; data management; design; interest; mathematical model; meetings; member; population based; programs; protocol violation; psychosocial; public education; repository; research study; response; sound; tool; web site

The Biostatistics Shared Resource (BSR) of the Mayo Clinic Cancer Center (MCCC) has provided expert statistical collaboration with MCCC investigators for over 35 years. The purpose is to provide statistical and biomathematical collaboration for the development and conduct of peer-reviewed cancer research generated by MCCC investigators. Research encompasses basic science, clinical trials, epidemiologic research, and other translational and educational research. The primary usage of CCSG funds is to support statistical and biomathematical collaboration on pilot projects, for assistance to investigators in developing approved research projects not otherwise funded but leading towards external funding, and to support unanticipated needs for statistical collaboration on MCCC approved projects. Over its history the BSR has undergone a natural and deliberate evolution and expansion, spurred by the expanding research activities of the MCCC. In the current grant period the BSR has successfully and strategically expanded in two primary areas: high dimensional genomic and proteomic data analysis (4 new faculty with this expertise), and to all 3 MCCC campuses. BSR faculty are physically located on all 3 MCCC campuses, and the entire resource communicates regularly and effectively through multiple mechanisms to ensure coordinated collaboration. The BSR has multiple focus areas (teams) tied together into a well-organized, efficient core. These are: (I) a Clinical Trials team responsible for cancer clinical trials, associated translational research, interventional psychosocial research, and patient and public education research projects, (II) a Population Science team responsible for providing statistical collaboration and data management support for cancer observational studies, including genetic and molecular epidemiology, (III) a Quality of Life team responsible for providing general and specific collaboration, measurement tools, and analysis for MCCC investigators investigating the impact of clinical and psychosocial interventions on cancer patients, families, caregivers, and others, and (IV) a Biomathematics team that provides collaborative expertise in the mathematical aspects of imaging, data processing and analysis, mathematical modeling of diease processes, and general mathematical or algorithmic issues. The BSR provides statistical and biomathematical collaboration to MCCC investigators across all three MCCC campuses. The resource has been remarkably productive, with 528 peer reviewed publications in the current grant period, and has collaborated on 104 NIH or NIH equivalent grants in the current grant period.

梅奥诊所癌症中心（MCCC）的生物统计学共享资源（BSR）提供了专家 与MCCC调查人员的统计合作已有35年以上。目的是提供统计和 生成的生物心理合作，用于开发和进行同行评审的癌症研究 由MCCC调查人员。研究包括基础科学，临床试验，流行病学研究和 其他翻译和教育研究。 CCSG资金的主要用法是支持统计和 试点项目的生物学合作，为调查人员提供协助开发批准的 研究项目没有其他资金，而是导致外部资金，并支持意外 在MCCC批准的项目上进行统计合作的需求。在其历史上，BSR经历了 MCCC的不断扩展的研究活动刺激了自然和故意的进化和扩张。 在当前的赠款期间，BSR在两个主要领域取得了成功，战略性的扩展：高 维度基因组和蛋白质组学数据分析（具有此专业知识的4个新教师），以及所有3个MCCC 校园。 BSR教职员工均位于所有3个MCCC校园中，整个资源 通过多种机制定期有效地进行沟通，以确保协作的协作。 BSR有多个焦点区域（团队），将其连接成一个组织良好，有效的核心。这些是：（i） 负责癌症临床试验，相关翻译研究，介入的临床试验团队 心理社会研究以及患者和公共教育研究项目，（ii）人口科学团队 负责为癌症观察提供统计协作和数据管理支持 研究，包括遗传和分子流行病学，（iii）一个负责提供的生活质量团队 MCCC调查人员的一般和特定协作，测量工具和分析 临床和社会心理干预对癌症患者，家庭，护理人员和其他人的影响，以及 （iv）一个生物制作团队，在成像的数学方面提供协作专业知识， 数据处理和分析，Diease过程的数学建模以及一般数学或 算法问题。 BSR向MCCC调查人员提供统计和生物学合作 在所有三个MCCC校园中。该资源非常有生产力，有528个同行评审 目前的赠款期间出版物，并在104个NIH或NIH等效赠款中合作 当前赠款期。