Clinical Molecular

临床分子

• 批准号: 6989452
• 负责人: LIONEL David LEWIS
• 金额: $ 10.23万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-02 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6989452
• 关键词: biomedical facility; diagnostic tests; evaluation /testing; high performance liquid chromatography; mass spectrometry; neoplasm /cancer; pharmacokinetics; tissue /cell preparation

The Clinical & Molecular Pharmacology Shared Resource (CMPSR) is an extension of the Clinical Pharmacology Shared Service. Its functions are to support NCCC investigators in the design, analysis, and interpretation of clinical pharmacology objectives in preclinical studies, clinical trials, chemoprevention trials and epidemiological studies. CMPSR services include: 1) a central processing center for biological fluid (plasma/saliva/urine) and cell samples obtained as part of approved clinical and epidemiological protocols, including processing of samples (including processing peripheral blood mononuclear cells), logging and storage, aliquoting, mail-outs; 2) development of novel drug assays (when such assays are not routinely available) using HPLC (UV & fluorescence detection) and liquid chromatography/mass spectrometry methodology; 3) performance of drug concentration measurements in biological fluids and tissues for formal, approved preclinical and clinical oncology studies and trials; 4) pharmacokinetic and pharmacodynamic analysis of data from pre-clinical animal trials and clinical studies; 5) development and performance of molecular biology assays for correlative science study endpoints in tissue (usually tumor tissue) for clinical oncology studies supported by the CMPSR; 6) consultation concerning clinical study design, and pharmacokinetic and pharmacodynamic hypothesis testing in studies; 7) assistance and participation in protocol scientific review (NCCC Cancer Research Committee) and the NCCC Safety and Data Monitoring Committee) within the NCCC.

临床和分子药理学共享资源（CMPSR）是临床的扩展 药理学共享服务。它的功能旨在支持NCCC研究者在临床研究，临床试验，化学预防试验和流行病学研究中的临床药理学目标的设计，分析和解释中。 CMPSR服务包括：1）作为批准的临床和流行病学方案的一部分获得的生物流体（血浆/唾液/尿液）的中央加工中心，包括样品的处理（包括处理外周血单核细胞），日志记录和存储，等分线，邮寄邮件； 2）使用HPLC（紫外线和荧光检测）和液相色谱/质谱法的开发新的药物测定（当时无法实现这种测定）； 3）在生物流体和组织中进行药物浓度测量的性能，用于正式，批准的临床前和临床肿瘤学研究和试验； 4）对临床前动物试验和临床研究数据的药代动力学和药效学分析； 5）针对CMPSR支持的临床肿瘤学研究组织（通常是肿瘤组织）中相关科学研究终点的分子生物学测定的开发和性能； 6）有关临床研究设计以及药代动力学和药效学的咨询 研究中的假设检验； 7）协助和参与协议科学审查（NCCC 癌症研究委员会）和NCCC安全与数据监测委员会） NCCC。