Rheumatic Disease Research Core Center

中心总体描述(申请人提供)： 我们建议在香港设立风湿病研究核心中心 田纳西大学健康科学中心，孟菲斯。风湿病研究进展 这个机构的疾病的特点是基础广泛， 涉及多个部门的多学科协作。我们有 确定了来自8个不同部门的26名科学家，他们拥有共同的 对风湿病发病机制的兴趣将成为 这个中心。这项提案的主题是“细胞外基质，自身免疫， 风湿性疾病中的细胞因子及其受体“，代表了它们 兴趣和专业知识。就个人而言，这些调查人员一直非常 取得了成功，该中心的目标是协调他们在 风湿病研究。这项建议的主要目标是 通过增强互动、效率、 和参与研究人员的工作效率；支持新的研究 指导；吸引新的研究人员到该领域；鼓励 其他学科的研究人员考虑与以下问题相关的研究 风湿性疾病；以及促进临床教师参与研究 和伙伴们。为支持这些目标，提出了3个核心。一个 管理核心将提供全面协调、外部审查和 支持浓缩活动。将准备一个分子资源核心 胶原蛋白，提供最先进的基因量化和发现，并执行 人类白细胞抗原DQ和DR分型。一个动物资源核心将提供具有良好特色的 转基因和基因敲除小鼠，以及相关细胞的流式细胞仪分析 在炎症中。每个核心都将在教育方面投入大量精力。 以及使用现代方法和途径治疗风湿病的培训 研究。建立试点和可行性方案，鼓励 创造性的努力。本申请包括3个项目，分别代表 新调查人员提出的创新建议。最近，UTHSC指定 结缔组织研究作为卓越的中心和承诺的实质性 支持新的招聘。这一承诺将增强我们的前景 成功。风湿病的强大机构支持，优越的体能 资源和良好的智力环境相结合，使之成为 这是在这个机构建立RDCC的好时机。

OVERALL CENTER DESCRIPTION (provided by applicant): We propose to establish a Rheumatic Diseases Research Core Center at the University of Tennessee Health Sciences Center, Memphis. Research in rheumatic diseases at this institution is characterized by a broad based, multidisciplinary collaboration involving several Departments. We have identified 26 scientists from 8 different Departments who share a common interest in rheumatic disease pathogenesis that will form the research base for this center. The theme of this proposal, "Extracellular matrix, Autoimmunity, Cytokines and their Receptors in Rheumatic Diseases", represents their interests and expertise. Individually, these investigators have been very successful and it is the goal of this center to coordinate their efforts in rheumatic disease research. The major objective of this proposal is to encourage rheumatic disease research by enhancing the interaction, efficiency, and productivity of the participating investigators; supporting novel research directions; attracting new investigators to the field; encouraging investigators in other disciplines to consider research in problems related to rheumatic diseases; and facilitating research involvement by clinical faculty and fellows. To support these objectives 3 cores are proposed. An Administrative Core will provide overall coordination, external review, and support for enrichment activities. A Molecular Resource Core will prepare collagen, provide state of the art gene quantitation and discovery, and perform HLA DQ and DR typing. An Animal Resources Core will provide well characterized transgenic and knock out mice, and flow cytometric analysis of cells involved in inflammation. Each of the cores will devote substantial effort to education and training in the use of modem methods and approaches to rheumatic disease research. We will establish a Pilot and Feasibility Program to encourage creative endeavors. Included in this application are 3 projects representing innovative proposals by new investigators. Recently, UTHSC designated Connective Tissue Research as a Center of Excellence and committed substantial support for new recruitment. This commitment will enhance our prospect for success. Strong institutional support for rheumatology, superior physical resources, and a favorable intellectual environment combine to make this an opportune time to establish an RDCC at this institution.