Rheumatic Disease Research Core Center

总体中心描述（由申请人提供）： 我们建议在香港大学设立风湿病研究核心中心， 田纳西大学健康科学中心，孟菲斯。风湿病研究 该机构的疾病特点是基础广泛， 涉及多个部门的多学科合作。我们有 确定了来自8个不同部门的26名科学家，他们有一个共同点， 对风湿性疾病发病机制的兴趣，将为 这个中心。本次提案的主题是“细胞外基质，自身免疫， 细胞因子及其受体在风湿性疾病中的作用”， 兴趣和专长。这些调查人员个人来说 成功，这是该中心的目标，以协调他们的努力， 风湿病研究。这项建议的主要目的是 通过加强互动、效率、 参与研究者的生产力;支持新的研究 吸引新的调查人员到外地;鼓励 其他学科的研究人员考虑研究与下列问题有关的问题： 风湿性疾病;促进临床教师参与研究 和伙伴们为了支持这些目标，提出了3个核心。一个 行政核心将提供总体协调、外部审查， 支持浓缩活动。分子资源核心将准备 胶原蛋白，提供最先进的基因定量和发现，并执行 HLA DQ和DR分型。动物资源核心将提供良好的特征 转基因和基因敲除小鼠，以及相关细胞的流式细胞术分析 炎症。每一个核心都将在教育方面投入大量精力 以及使用现代方法和手段治疗风湿病的培训 research.我们将建立一个试点和可行性计划，以鼓励 创造性的努力。本申请中包括3个项目， 新调查员的创新建议。最近，UTHSC指定 结缔组织研究作为一个卓越的中心，并致力于大量的 支持新招聘。这一承诺将加强我们的前景， 成功强大的风湿病学机构支持，上级物理 资源，和良好的智力环境联合收割机相结合，使之成为一个 在这个机构建立一个RDCC的适当时机。

OVERALL CENTER DESCRIPTION (provided by applicant): We propose to establish a Rheumatic Diseases Research Core Center at the University of Tennessee Health Sciences Center, Memphis. Research in rheumatic diseases at this institution is characterized by a broad based, multidisciplinary collaboration involving several Departments. We have identified 26 scientists from 8 different Departments who share a common interest in rheumatic disease pathogenesis that will form the research base for this center. The theme of this proposal, "Extracellular matrix, Autoimmunity, Cytokines and their Receptors in Rheumatic Diseases", represents their interests and expertise. Individually, these investigators have been very successful and it is the goal of this center to coordinate their efforts in rheumatic disease research. The major objective of this proposal is to encourage rheumatic disease research by enhancing the interaction, efficiency, and productivity of the participating investigators; supporting novel research directions; attracting new investigators to the field; encouraging investigators in other disciplines to consider research in problems related to rheumatic diseases; and facilitating research involvement by clinical faculty and fellows. To support these objectives 3 cores are proposed. An Administrative Core will provide overall coordination, external review, and support for enrichment activities. A Molecular Resource Core will prepare collagen, provide state of the art gene quantitation and discovery, and perform HLA DQ and DR typing. An Animal Resources Core will provide well characterized transgenic and knock out mice, and flow cytometric analysis of cells involved in inflammation. Each of the cores will devote substantial effort to education and training in the use of modem methods and approaches to rheumatic disease research. We will establish a Pilot and Feasibility Program to encourage creative endeavors. Included in this application are 3 projects representing innovative proposals by new investigators. Recently, UTHSC designated Connective Tissue Research as a Center of Excellence and committed substantial support for new recruitment. This commitment will enhance our prospect for success. Strong institutional support for rheumatology, superior physical resources, and a favorable intellectual environment combine to make this an opportune time to establish an RDCC at this institution.