Mayo Comprehensive Cancer Center Grant

简介（由申请人提供）：梅奥诊所癌症中心的使命是促进和促进癌症发病率、病因和进展的基础和临床研究，然后通过教育和直接应用这些研究成果，将发现转化为癌症预防、检测、诊断、预后和治疗的改进方法。最终目标是减轻癌症患者的疾病负担。因此，梅奥诊所癌症中心的研究是广泛和跨学科的，但高度关注癌症。专业和公众教育活动出色而广泛，患者的临床和心理社会护理质量最高，具有人文精神。这些综合特征构成了我们请求CCSG支持并继续被国家癌症研究所指定为综合癌症中心的基础。科学目标是通过12个研究项目来实现的，这些研究项目的成员主要来自罗切斯特的梅奥诊所，但也来自杰克逊维尔和斯科茨代尔的组成部分。十二个研究项目是：遗传流行病学和风险评估；癌症防治；细胞生物学；发展治疗;癌症成像;免疫学和免疫治疗；基因与病毒治疗；前列腺癌;血液恶性肿瘤;Neuro-oncology;女性癌症：和胃肠道癌症。这意味着自上次审查以来，净增加了5个项目。18项共享资源支持科学倡议。梅奥诊所癌症中心的科学和财政管理现在是稳定的，经验丰富的，健全的，我们在梅奥基金会领导的所有三个梅奥中心的活动中得到了持续和实质性的支持。未来的计划将坚定不移地专注于创建和维持一个癌症中心，利用自己的科学能力和成就，以及其他人的成就，为全球癌症患者谋取利益。因此，大量的注意力被放在研究项目上，阐明癌症病因的基本机制，优化我们确定疾病风险因素的能力，从而实现更好的预防，更好的早期诊断工具的开发，分层疾病的新疗法的设计，以及改善患者的生活质量，特别是通过基于神经生物学的方法来缓解疼痛。

DESCRIPTION (provided by applicant): The mission of the Mayo Clinic Cancer Center is to promote and facilitate basic and clinical research on the incidence, etiology, and progression of cancer, and then through education and direct application of the results of such research, translate the discoveries into improved methods for cancer prevention, detection, diagnosis, prognosis, and therapy. The ultimate goal is to relieve the burdens of illness in patients with cancer. Accordingly, Mayo Clinic Cancer Center research is broad and interdisciplinary, but highly cancer focused. Professional and public education activities are excellent and expansive, and clinical and psychosocial care of patients are of the highest quality and humanistic. These aggregate characteristics form the basis for our request for CCSG support and to continue our designation by the National Cancer Institute as a Comprehensive Cancer Center. The scientific objectives are met through twelve research programs whose members are drawn mostly from the principal site at Mayo Clinic Rochester, but also from components at Jacksonville and Scottsdale. The twelve research programs are: Genetic Epidemiology and Risk Assessment; Cancer Prevention and Control Cell Biology; Developmental Therapeutics; Cancer Imaging; Immunology and Immunotherapy; Gene and Virus Therapy; Prostate Cancer; Hematologic Malignancies; Neuro-oncology; Women's Cancer: and Gastrointestinal Cancer. This represents a net increase of five programs since our last review. Eighteen shared resources support the scientific initiatives. Scientific and fiscal administration of the Mayo Clinic Cancer Center is now stable, experienced, and robust, and we enjoy consistent and substantial support from Mayo Foundation leadership for our activities at all three Mayo sites. Plans for the future are guided by an uncompromising focus on creating and sustaining a Cancer Center that uses its own scientific capabilities and achievements and those of others for the gain of patients with cancer globally. Accordingly, substantial attention is being paid to research programs which elucidate the basic mechanisms of cancer etiology and optimize our ability to determine disease risk factors, thereby enabling better prevention, the development of better tools for early diagnosis, the design of novel therapeutics for stratified diseases, and the improvement of patients' quality of life, especially through neurobiologically based methods for palliation of pain.