Mayo Comprehensive Cancer Center Grant

描述（由申请人提供）：马约诊所癌症中心的使命是促进和促进有关癌症发病率、病因学和进展的基础和临床研究，然后通过教育和直接应用此类研究结果，将发现转化为癌症预防、检测、诊断、预后和治疗的改进方法。最终目标是减轻癌症患者的疾病负担。因此，马约诊所癌症中心的研究是广泛和跨学科的，但高度集中在癌症。专业和公共教育活动是优秀和广泛的，病人的临床和心理社会护理是最高质量和人性化的。这些综合特征构成了我们请求CCSG支持的基础，并继续被美国国家癌症研究所指定为综合癌症中心。科学目标通过12个研究项目实现，这些项目的成员主要来自马约诊所罗切斯特的主要研究中心，但也来自杰克逊维尔和斯科茨代尔的组成部分。12个研究项目是：遗传流行病学和风险评估;癌症预防和控制细胞生物学;发育治疗学;癌症成像;免疫学和免疫治疗;基因和病毒治疗;前列腺癌;血液肿瘤;神经肿瘤学;妇女癌症和胃肠道癌症。这表明自上次审查以来净增加了五个方案。18个共享资源支持科学举措。 马约诊所癌症中心的科学和财政管理现在是稳定的，经验丰富的，强大的，我们享有一致的和实质性的支持，从马约基金会领导我们的活动在所有三个马约网站。未来的计划是由一个毫不妥协的重点，建立和维持一个癌症中心，利用自己的科学能力和成就，以及其他人的癌症患者的全球收益为指导。因此，大量的注意力被放在阐明癌症病因学的基本机制和优化我们确定疾病风险因素的能力的研究项目上，从而能够更好地预防，开发更好的早期诊断工具，设计分层疾病的新疗法，以及改善患者的生活质量，特别是通过基于神经生物学的方法缓解疼痛。

DESCRIPTION (provided by applicant): The mission of the Mayo Clinic Cancer Center is to promote and facilitate basic and clinical research on the incidence, etiology, and progression of cancer, and then through education and direct application of the results of such research, translate the discoveries into improved methods for cancer prevention, detection, diagnosis, prognosis, and therapy. The ultimate goal is to relieve the burdens of illness in patients with cancer. Accordingly, Mayo Clinic Cancer Center research is broad and interdisciplinary, but highly cancer focused. Professional and public education activities are excellent and expansive, and clinical and psychosocial care of patients are of the highest quality and humanistic. These aggregate characteristics form the basis for our request for CCSG support and to continue our designation by the National Cancer Institute as a Comprehensive Cancer Center. The scientific objectives are met through twelve research programs whose members are drawn mostly from the principal site at Mayo Clinic Rochester, but also from components at Jacksonville and Scottsdale. The twelve research programs are: Genetic Epidemiology and Risk Assessment; Cancer Prevention and Control Cell Biology; Developmental Therapeutics; Cancer Imaging; Immunology and Immunotherapy; Gene and Virus Therapy; Prostate Cancer; Hematologic Malignancies; Neuro-oncology; Women's Cancer: and Gastrointestinal Cancer. This represents a net increase of five programs since our last review. Eighteen shared resources support the scientific initiatives. Scientific and fiscal administration of the Mayo Clinic Cancer Center is now stable, experienced, and robust, and we enjoy consistent and substantial support from Mayo Foundation leadership for our activities at all three Mayo sites. Plans for the future are guided by an uncompromising focus on creating and sustaining a Cancer Center that uses its own scientific capabilities and achievements and those of others for the gain of patients with cancer globally. Accordingly, substantial attention is being paid to research programs which elucidate the basic mechanisms of cancer etiology and optimize our ability to determine disease risk factors, thereby enabling better prevention, the development of better tools for early diagnosis, the design of novel therapeutics for stratified diseases, and the improvement of patients' quality of life, especially through neurobiologically based methods for palliation of pain.