Core--Organic Synthesis - Synthesis of Lipid Mediators

化学核心将通过合成和分析正在研究的特定新型脂质介质，为本研究项目提供必要的化学支持。该核心将负责化学合成所需数量（高达毫克级）的一组生物活性脂毒素、溶解素、二十二碳三烯、二磷酸前烯衍生物和相关脂质介质，这些物质将用于研究它们在解决与牙周病相关的炎症中的作用。化学核心将开发和优化所需的合成途径，以制备立体化学纯形式的选定脂质介质，并将进行它们的全合成，详细纯化和结构验证。

The Chemistry Core will provide essential chemistry support for this Research Program through the synthesis and analysis of the specific novel lipid mediators being studied. This Core will be responsible for the chemical synthesis of the required quantities (up to milligram-scale) of a panel of bioactive lipoxins, resolvins, docosatrienes, presqualene diphosphate derivatives and related lipid mediators that will be used to study their role in the resolution of inflammation associated with periodontal disease. The Chemistry Core will develop and optimize the required synthetic pathways for the preparation of the selected lipid mediators in a stereochemically pure form and will carry out their total synthesis, detailed purification and structural verification. The Chemistry Core will also collaborate closely with the other Sub-Projects on the identification, structural elucidation and study of the targeted lipid mediators and will help prepare isotopically labeled derivatives for receptor binding studies. Overall, the work performed in the Chemistry Core is essential for studying the key actions of the lipid mediators studied in this Program, for elucidating the their role in the signaling pathways involved in resolution, and for establishing their potential "pro-resolution" and anti-inflammatory roles.