Psychophysics and Biological bases of taste alterations in radiotherapy patients:

放疗患者味觉改变的心理物理学和生物学基础：

• 批准号: 6819584
• 负责人: Paul A. S Breslin
• 金额: $ 33.52万
• 依托单位: MONELL CHEMICAL SENSES CENTER
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-15 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6819584
• 关键词: anorexia; chemical hypersensitivity; chemosensitizing agent; clinical research; computational neuroscience; histology; human subject; human therapy evaluation; immunocytochemistry; inflammation; irritation /irritant; mass spectrometry; medical complication; neuropsychological tests; olfactory disorder; pathologic process; patient oriented research; perception disorder; psychophysics; radiation therapy; regeneration; sensory mechanism; sinusitis; statistics /biometry; taste disorders

Clinical taste deficits are rare disorders in the general population that occur at a rate well below that of olfactory loss (see Core). The dearth of taste patients renders the study of taste disorders difficult and, consequently, their treatment problematic. Yet, there is one prominent exception to this generalization; over 90% of all head and neck cancer patients who receive radiation therapy (radiotherapy) experience substantial taste loss and alterations of food flavor perception. These changes are major contributors to decreased food intake, anorexia, and weight loss. They also contribute to a significant decrement in general quality of life and an increase in suffering. Neither the full impact of radiotherapy on taste perception, nor the exact bases for gustatory abnormalities associated with it, is known. Radiotherapy may chronically alter the gustatory epithelia via repeated inflammatory insult, subsequent fibrotic and anti-vascular sequellae, and/or by genetic alteration of the epithelial/gustatory regenerative cellular processes. The long-term goals of this muttidisciplinary research program are: (1) to carefully document the magnitude, quality, and course of taste perception changes resulting from radiotherapy; (2) to simultaneously document morphological, histological, and molecular changes in the gustatory system that follow radiotherapy and relate these to observed perceptual changes; (3) to determine whether long-term gustatory deficits and abnormalities are caused by repeated, accumulated inflammatory insult, radiation-induced genetic alteration of reconstructive cells and stem cells, and/or the epithelial sequellae of these events, in order to begin to understand the causes of these abnormalities. This understanding will yield insight into potential therapeutic interventions for patients. It is also anticipated that the results will consummate in the development of patient outcome profiles providing important prognostic information to patients and their physicians and, ultimately, improve patient care and quality of life. Finally, information about how insult from radiation treatment compromises taste function may provide new insights into fundamental processes underlying normal orosensory biology.

临床味觉缺陷在普通人群中是罕见的疾病，其发生率远低于嗅觉丧失（见核心）。味觉患者的缺乏使味觉障碍的研究变得困难，因此，他们的治疗问题重重。然而，这种概括有一个明显的例外；超过90%接受放射治疗（放疗）的头颈癌患者经历了严重的味觉丧失和食物风味感知的改变。这些变化是食物摄入减少、厌食症和体重减轻的主要原因。它们还会导致总体生活质量的显著下降