Characterizing SARS-CoV-2 infection of human taste cells in culture

摘要 补助目标与父母补助的相关性 在父母补助金中，我们使用培养的人类味觉（HBO）细胞，由共同研究员哈坎在莫内尔开创 Ozdener，以探测代谢甜味信号通路。高压氧细胞提供了一个有用的模型， 味觉信号在文化中，但他们也被证明是有用的，用于调查某些病理生理学， 神经营养性病毒疾病（例如寨卡病毒;参见Ozdener et al.，2020年）。使用HBO细胞来完成 补充目标将促进我们对SARS-CoV-2和其他病毒的致病性的理解， 不利地影响味觉和嗅觉。尽管许多研究报告了个体的味觉和嗅觉丧失 对于COVID-19疾病，味觉细胞中的潜在机制和细胞效应尚不清楚。 由于COVID-19患者的味觉功能发生了变化，父母补助金将特别关注 知道甜味细胞的亚群是否对SARS-CoV-2感染敏感。

Abstract Relatedness of Supplement Aim to Parent Grant In the parent grant, we use cultured human taste (HBO) cells, pioneered at Monell by Co-Investigator Hakan Ozdener, to probe the metabolic sweet taste signaling pathway. HBO cells provide a useful model for probing taste signaling in culture, but they have also been shown useful for investigating the pathophysiology of certain neurotrophic viral diseases (e.g. Zika virus; see Ozdener et al., 2020). Using HBO cells to accomplish the Supplement Aim will advance our understanding of the pathogenicity of SARS-CoV-2 and other viruses that adversely affect taste and olfaction. Although many studies have reported taste and olfactory loss in individuals with COVID-19 disease, the underlying mechanisms and cellular effects in taste cells are not well understood. Due to changes in taste function in patients with COVID-19, it will be of particular interest to the parent grant to know if the subset of sweet taste cells is susceptible to infection by SARS-CoV-2.