Renal Inflammation: Mechanisms and Consequences

描述(由申请人提供) O‘Brien肾脏炎症中心的使命是促进我们对肾脏疾病炎症发生、维持和消退的机制的了解。肾脏炎症被认为在急性肾功能衰竭、肾小球肾炎、糖尿病肾病、高血压和进行性肾脏疾病的发病机制中起关键作用。在这个中心的应用中，我们聚集了在炎症不同方面具有专业知识的科学家，以提供对肾脏炎症所涉及的机制的全面而有凝聚力的研究。多学科方法将侧重于促炎和抗炎机制，重点放在那些没有得到太多关注的分子(例如尿酸)或最近才被确定在炎症中起作用的分子。后者包括新的趋化因子(CXCL16)、新的黏附分子(JAM家族)、最近发现的Sit/Robo家族、信号分子Smad7和锡钙素。一个专注于这些分子在人类疾病中作用的病理学核心将提供临床相关性，并将成为一种机制，将基础科学观察转化为潜在的未来临床研究应用。该中心还将培训学术肾病领域的奖学金候选人(与目前正在审查中的T-32培训补助金一起)，帮助初级研究人员开始职业生涯(通过DR/P&F计划)，并与贝勒的其他同样关注炎症反应的中心(如炎症生物学中心)提供强有力的互动。研究肾脏炎症的综合、多学科、协同和综合的方法将有助于更好地了解肾脏疾病的发病机制，并可能提供新的治疗见解。

DESCRIPTION (provided by applicant) The O'Brien Center for Renal Inflammation has the mission of furthering our understanding of the mechanisms involved in the initiation, maintenance, and resolution of inflammation in renal disease. Renal inflammation is recognized to have a critical role in the pathogenesis of acute renal failure, glomerulonephritis, diabetic nephropathy, hypertension, and progressive renal disease. In this Center application, we have brought together scientists with expertise in different aspects of inflammation to provide a cohesive and comprehensive investigation of the mechanisms involved in renal inflammation. The multidisciplinary approach will focus on both proinflammatory and anti-inflammatory mechanisms with an emphasis on molecules that have either not received much attention (e.g., uric acid) or that have only recently been identified as having a role in inflammation. The latter includes new chemokines (CXCL16), new adhesion molecules (JAM family), the recently discovered Slit/Robo family, the signaling molecule Smad7, and stanniocalcin. A pathology core that focuses on the role of these molecules in human disease will provide clinical relevance and will be a mechanism for translating basic science observations for potential future clinical research application. The Center will also train fellowship candidates for a career in academic nephrology (in concert with a T-32 training grant which is currently under review), help initiate the careers of junior investigators (via the DR/P&F program), and provide a strong interaction with the other Centers at Baylor that also focus on the inflammatory response (such as the Biology of Inflammation Center). The integrated, multidisciplinary, synergistic and comprehensive approach to study renal inflammation should provide a better understanding of the pathogenesis of renal disease and may provide new therapeutic insights.