Research Training in Renal Disease

肾病研究培训

• 批准号: 6735604
• 负责人: HUI Y LAN
• 金额: $ 17.81万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6735604
• 关键词: Research; Training; Renal; Disease

DESCRIPTION (provided by applicant):The objective of this training program is to provide superb training of bright, young physician-scientists to develop the necessary skills to conduct state-of-the-art basic and translational research in the field of nephrology. The emphasis of the program is to provide training in the experimental design, methodology, and analyses of research aimed at elucidating mechanisms of renal injury and scarring as it relates to renal diseases associated with hypertension, diabetes, glomerular disease, and other renal conditions. The ultimate goal is to train physician-scientists to become independent investigators in academic nephrology. To achieve this objective, a multidisciplinary program has been developed to provide individualized training to postdoctoral candidates. Selected candidates develop a research project in concert with both a Nephrology and Basic Science mentor and undertake a minimum of two and preferably 3 years of research in their respective laboratories. A strong didactic program is also provided to ensure teaching in experimental design, molecular biologic methodology, biostatistics, and ethics. The emphasis of the program centers on several major areas of renal inflammation and fibrosis. These include the role of effector cells (macrophages and T cells) and their mechanisms of recruitment and dispersal, including the biology of chemokines, leukocyte adhesion molecules, the Slit/Robo chemorepellant molecules, monocyte/macrophage migration inhibition factor, and macrophage activation, proliferation and apoptosis. The cellular mechanisms involved in the renal response to injury will also be studied in detail, including the role of impaired angiogenesis, tubular apoptosis, and mechanisms of fibrosis. The latter includes the role of cytokines (IL-1beta and TNFalpha), TGF-beta/Smad signaling, the role of MAP kinases, and of the ubiquitination/proteasomal system in cytokine receptor degradation and cytokine unresponsiveness. Additional emphasis is placed on mechanisms of smooth muscle cell injury and proliferation in the kidney, particularly as it relates to the development of hypertension, and the various biochemical (such as uric acid) and vasoactive mediators (such as stanniocalcin) that influence smooth muscle cell proliferation, migration, hypertrophy and contraction. The interdisciplinary, multi-faceted plan integrates several important fields (biochemistry, immunology, physiology and pathology) to dissect structure function relationships linking basic cellular signaling and molecular mechanisms with translational research in animal models of disease.

描述(由申请者提供)：该培训计划的目标是为聪明、年轻的内科科学家提供卓越的培训，以发展必要的技能，以在肾脏病领域进行最先进的基础和翻译研究。该计划的重点是提供实验设计、方法和研究分析方面的培训，旨在阐明肾脏损伤和疤痕形成的机制，因为它与高血压、糖尿病、肾小球疾病和其他肾脏疾病有关。最终目标是培养内科科学家成为学术肾病领域的独立研究人员。为了实现这一目标，已经开发了一个多学科计划，为博士后候选人提供个性化培训。选定的候选人与一名肾病学和基础科学导师共同开展研究项目，并在各自的实验室进行至少两年、最好是三年的研究。还提供了一个强大的教学计划，以确保在实验设计，分子生物学方法论，生物统计学和伦理学的教学。该计划的重点是肾脏炎症和纤维化的几个主要领域。这些包括效应细胞(巨噬细胞和T细胞)的作用及其募集和扩散机制，包括趋化因子的生物学，白细胞黏附分子，Sit/Robo趋化分子，单核/巨噬细胞移动抑制因子，以及巨噬细胞的激活，增殖和凋亡。还将详细研究肾损伤反应的细胞机制，包括血管生成受损的作用、肾小管细胞凋亡和纤维化机制。后者包括细胞因子(IL-1β和TNFα)、转化生长因子-β/Smad信号转导、MAP激酶的作用以及泛素化/蛋白酶体系统在细胞因子受体降解和细胞因子无反应中的作用。此外，还强调了肾脏中的平滑肌细胞损伤和增殖的机制，特别是当它与高血压的发展有关时，以及影响平滑肌细胞增殖、迁移、肥大和收缩的各种生化(如尿酸)和血管活性介质(如锡钙素)。这项跨学科、多层面的计划整合了几个重要领域(生物化学、免疫学、生理学和病理学)，以剖析结构功能关系，将基本的细胞信号和分子机制与疾病动物模型的翻译研究联系起来。