Investigation of phage-host and human cell interactions via the biochemical and structural analysis of host cell receptors

通过宿主细胞受体的生化和结构分析研究噬菌体-宿主和人类细胞的相互作用

• 批准号: 2391878
• 金额: --
• 依托单位: University of Warwick
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2391878
• 关键词: Investigation; phage; host; human; cell

Bacteriophages are viruses that target their host bacteria with great specificity and can therefore be used as therapeutics, in a process known as phage therapy. In order to understand better the mechanisms of phage therapy, we need to investigate in more details the phage-host and human cells interaction.In this project, using phage biology, human cell biology, confocal microscopy, biochemistry and structural biology, we wish to investigate further the interactions between phage-host and human cells, with final goal the better understanding of the factors that are of importance in the success of phage therapy.

噬菌体是一种以宿主细菌为目标的病毒，具有很强的特异性，因此可以在称为噬菌体治疗的过程中用作治疗剂。为了更好地理解噬菌体治疗的机制，我们需要更详细地研究噬菌体-宿主和人细胞之间的相互作用，本项目利用噬菌体生物学、人细胞生物学、共聚焦显微镜、生物化学和结构生物学等技术，进一步研究噬菌体-宿主和人细胞之间的相互作用，最终目标是更好地理解噬菌体治疗成功的重要因素。