Weight Loss and CVD Risk Factors

描述（由申请人提供）：如果个人减肥获得BMI为25，他们是否平均获得了在一段时间内保持BMI为25的个人的风险因素特征？目前，几乎没有证据可以回答这个问题。减肥对糖尿病和心血管疾病（CVD）风险因素的有益影响已有充分的记录，然而，较高体重对风险因素的影响尚不清楚。个人可能会为过去的肥胖付出代价，这似乎是合乎逻辑的，因此目前体重相同的个人将根据他们的体重历史而具有不同的风险状况。 然而，目前尚不清楚以前体重较重的人（即，体重减轻）与具有体重维持史的类似体重的个体相比保持更高的风险。 这里提议的研究将： 1.确定与保持体重的具有相同BMI（在间隔结束时）的个体相比，减肥的个体是否获得不同的CVD风险因素平均水平。 2.确定体重维持者和体重减轻者（如目标1所定义）的CVD风险因素在两组体重维持一年后是否不同。 3.确定身体活动、身体健康和节食是否会导致体重保持者和体重减轻者之间的差异（如目标1和2所定义）。 我们将通过对有氧运动中心纵向研究（ACLS）现存数据的分析来实现这些目标。检查的风险因素将包括空腹血糖、收缩压和舒张压、总胆固醇、LDL胆固醇、HDL胆固醇和甘油三酯。ACLS队列中评估的体重和CVD风险因素的重复测量使其成为这些分析的丰富来源。这项研究将对理解和澄清减肥的可能益处产生强烈的影响。拟议项目响应PA-03-015。

DESCRIPTION (provided by applicant): If individuals lose weight to acquire a BMI of 25, do they, on average, acquire the risk factor profile of individuals who have over a period of time maintained a BMI of 25? Currently there is little evidence on which to base a response to this question. The beneficial effects of weight loss on risk factors for diabetes and cardiovascular disease (CVD) are well documented, however, the effect of a history of higher weight on risk factors is unclear. It seems logical that individuals might pay a price for past obesity, such that individuals currently at the same weight would have different risk profiles depending on their weight history. Nevertheless, it is not clear if individuals who were previously heavier (i.e., lost weight) retain a higher risk compared to individuals of similar weight with a history of weight maintenance. The research proposed here will: 1. Determine whether individuals who lose weight attain different mean levels of risk factors for CVD compared to individuals with the same BMI (at the end of the interval) who maintained their weight. 2. Determine whether CVD risk factors in weight maintainers and weight losers (as defined in Aim 1) are different after an additional year in which both groups maintained weight. 3. Establish whether physical activity, physical fitness, and dieting contribute to differences between weight maintainers and weight losers (as defined in Aims 1 and 2). We will accomplish these aims through analysis of extant data from the Aerobics Center Longitudinal Study (ACLS). Risk factors examined will include fasting glucose, systolic and diastolic blood pressure, total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides, The repeated measures of body weight and CVD risk factors assessed in the ACLS cohort make it a rich source for these analyses, This research will have strong implications for understanding and clarifying the possible benefits of weight loss, The proposed project is responsive to PA-03-015.