The impact of ultra-processed food intake on neural, metabolic, and hormonal aspects of weight regulation.

超加工食品摄入对体重调节的神经、代谢和激素方面的影响。

• 批准号: 2394593
• 金额: --
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2394593
• 关键词: impact; ultra; processed; food; intake

As defined by the NOVA classification, ultra-processed foods are associated with an increased risk of obesity, metabolic syndrome, cancer, cardiovascular disease and all-cause mortality. Ultra-processed foods tend to be poorly satiating and more hyperglycaemic than minimally-processed alternatives, and have been shown to cause energy overconsumption and weight gain compared with a minimally-processed diet. This has led to public health calls to limit or even omit ultra-processed food intake altogether from the human diet. However, mechanistic evidence to support a link between ultra-processed food intake and poor health is largely theoretical, and evidence from well-designed interventional studies are scarce.Therefore, the aims of this PhD are to investigate the neural, metabolic and hormonal changes associated with a high-ultra-processed-food diet, compared with a low-ultra-processed-food diet.The impact of consuming diets with varying amounts of ultra-processed food content on anthropometric, hormonal, metabolic and inflammatory indices, sleep, activity and brain connectivity will be investigated.The findings from this PhD will provide important insights into how ultra-processed foods influence brain function, neural connectivity, metabolism and hormonal activity, and provide direct evidence on the health impact of reducing ultra-processed food intake.

根据 NOVA 分类的定义，超加工食品会增加肥胖、代谢综合征、癌症、心血管疾病和全因死亡率的风险。与最低限度加工的替代品相比，超加工食品往往缺乏饱腹感，并且血糖更高，并且与最低限度加工的饮食相比，已被证明会导致能量过度消耗和体重增加。这导致公共卫生部门呼吁限制甚至完全消除人类饮食中的超加工食品摄入量。然而，支持超加工食品摄入与不良健康之间联系的机制证据很大程度上是理论上的，精心设计的干预研究的证据很少。因此，本博士的目的是研究与低超加工食品饮食相比，高超加工食品饮食相关的神经、代谢和激素变化。不同摄入量饮食的影响 将研究超加工食品含量对人体测量、激素、代谢和炎症指数、睡眠、活动和大脑连接的影响。该博士的研究结果将为超加工食品如何影响大脑功能、神经连接、新陈代谢和激素活动提供重要见解，并为减少超加工食品摄入对健康的影响提供直接证据。