Optical monitoring of cerebral oxygenation in infants

婴儿脑氧合的光学监测

• 批准号: 6729110
• 负责人: Maria Angela Franceschini
• 金额: $ 37.25万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2006-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6729110
• 关键词: biomedical equipment development; brain disorder diagnosis; brain injury; cerebrovascular system; clinical biomedical equipment; clinical research; early diagnosis; human subject; infrared spectrometry; injury prevention; newborn human (0-6 weeks); oximetry; oxygen tension; oxygen transport; patient monitoring device; patient oriented research; respiratory oxygenation; swine

DESCRIPTION (provided by applicant): Oxygen deprivation, typically the result of a combination of hypoxia and hypoperfusion, is often the primary event setting off a biochemical cascade that leads to irreversible brain injury in perinatal encephalopathy. The long-term objective of this project is the development of a novel near-infrared spectroscopy (NIRS) device for the continuous monitoring of the regional tissue saturation (St02), arterial saturation (Sa02), and venous saturation (Sv02) in the neonate's brain. Such a device could potentially detect brain tissue compromise before the development of irreversible structural damage, thus allowing for timely and specific intervention. The novelty of our approach relates to the hypothesis that an appropriate temporal analysis of NIRS data can yield three different oxygenation measurements: (1) St02 from the temporal average of the optical signal; (2) Sa02 from the oscillating component of the optical absorption at the pulse frequency; (3) Sv02 from the oscillating component of the optical absorption at the respiratory frequency. The short-term goals of this project are to characterize NIRS measurements of cerebral oxygenation and to identify the most effective practical implementation of NIRS (in terms of instrumentation and data processing) for non-invasive cerebral oximetry. In particular, we aim to 1 ) investigate the relationship between the local measurements of the hemoglobin oxygenation in the cerebral tissue, in the arterial vascular compartment, and in the venous vascular compartment, and 2) perform spatially resolved measurements of cerebral oxygenation to localize areas of brain damage. To achieve our short-term goals, we propose to perform measurements on an animal model (piglets) where we can induce changes in the hemoglobin oxygenation levels over a large range, where we can perform hemodilution experiments, where we can induce focal brain injury, and where we have access to invasive readings of Sa02 and Sv02 from the gas analysis of blood samples. Finally we will test our proposed NIRS approach to cerebral oximetry on human neonates. The completion of this study will lead to the characterization of NIRS oximetry of the brain, to the development of multimode optical oximetry (simultaneous local measurement of St02, Sa02, and Sv02), and to the identification of the most effective approach to the non-invasive. continuous monitoring of cerebral oxygenation in neonates.

描述（由申请人提供）：缺氧，通常是缺氧和灌注不足的组合的结果，通常是引发生化级联反应的主要事件，导致围产期脑病的不可逆脑损伤。该项目的长期目标是开发一种新型近红外光谱（NIRS）设备，用于连续监测新生儿大脑中的局部组织饱和度（St 02）、动脉饱和度（Sa 02）和静脉饱和度（Sv 02）。这样的设备可能会在不可逆的结构损伤发生之前检测到脑组织受损，从而允许及时和具体的干预。我们的方法的新奇与以下假设有关：对NIRS数据进行适当的时间分析可以产生三种不同的氧合测量值：（1）来自光学信号的时间平均值的St 02;（2）来自脉冲频率下的光学吸收的振荡分量的Sa 02;（3）来自呼吸频率下的光学吸收的振荡分量的Sv 02。该项目的短期目标是表征脑氧合的近红外光谱测量，并确定最有效的实际实施近红外光谱（仪器和数据处理方面）的非侵入性脑血氧测定。特别是，我们的目标是1）调查脑组织中，动脉血管室中，静脉血管室中的血红蛋白氧合的局部测量之间的关系，和2）进行脑氧合的空间分辨测量，以定位脑损伤的区域。为了实现我们的短期目标，我们建议对动物模型（小猪）进行测量，在该动物模型中，我们可以在大范围内诱导血红蛋白氧合水平的变化，在该动物模型中，我们可以进行血液稀释实验，在该动物模型中，我们可以诱导局灶性脑损伤，并且在该动物模型中，我们可以从血液样品的气体分析中获得Sa 02和Sv 02的侵入性读数。最后，我们将测试我们提出的NIRS方法对人类新生儿脑血氧饱和度。这项研究的完成将导致表征大脑的NIRS血氧饱和度，多模式光学血氧饱和度的发展（同时局部测量St 02，Sa 02和Sv 02），并确定最有效的方法，以非侵入性。连续监测新生儿脑氧合。