Fetal pancreatic development & insulin secretion
Fetal pancreatic development & insulin secretion
批准号:
6723802
负责人:
William W Hay
金额:
$50.33万
依托单位国家:
美国
项目类别:
财政年份:
2002
资助国家:
美国
项目状态:
已结题
起止时间:
2002-04-01 至 2007-03-31
关键词:
SCID mouseaminoacidcell transplantationdiet therapyembryo /fetusembryogenesisgene expressionglucosehistogenesishormone regulation /control mechanismhormone therapyimmunocytochemistryinsulininsulinlike growth factormammalian embryologymetabolismmother /embryo /fetus nutritionnonhuman therapy evaluationnorthern blottingsnutrient interactionnutrition related tagpancreaspancreatic islet functionprenatal growth disordersheepwestern blottings
中文摘要
说明:(申请人提供)本研究项目的目标是
了解调节胰腺发育和功能的机制,
受营养素和次级内分泌因素的影响,
营养素的影响,并特别关注有限的胰腺生长
和功能在胎儿宫内生长受限(IUGR)。我们将
验证胎盘功能不全导致胎儿营养减少的假设
将导致主要营养素(葡萄糖)和次要激素(胰岛素,
胰岛素样生长因子(IGFs)缺乏导致胰腺内分泌发育异常,
有三个具体目标。
1.分析胰腺发育和功能,以确定关键发育
时期,并确定适应所施加的养分供应减少
在IUGR胎儿中。
2.确定营养和激素缺乏对胰岛素的影响
在IUGR胎儿胰腺内分泌细胞中的产生和分泌。
3.通过以下方式测试恢复正常胰腺发育和功能的能力:
关键时期的体内营养和激素补充
IUGR胎儿的发育。
拟议的研究将在我们的IUGR绵羊模型中进行,
母亲在怀孕期间暴露于中度高温环境。
这些胎儿会发生低血糖和低氨基酸血症,
在妊娠的后三分之一胰岛素和GF浓度的不足。
体内和体外研究将表征胰腺发育,
功能和确定机制负责胰腺异常,
是胎儿营养缺乏的直接后果这些研究还将
深入了解临床干预的要求,以改善
IUGR胎儿和新生儿的胰腺功能不全,
胎儿和新生儿的发病率和死亡率,并有可能减少
与低出生率有关的成人发病率
重量.
英文摘要
DESCRIPTION: (Provided By Applicant)The goal of this research project is to
understand mechanisms regulating pancreatic development and function that are
influenced by nutrients and secondary endocrine factors that augment the
effects of nutrients and to focus specifically on the limited pancreatic growth
and function in fetuses with intrauterine growth restriction (IUGR). We will
test the hypothesis that reduced fetal nutrition from placental insufficiency
will result in primary nutrient (glucose) and secondary hormonal (insulin,
IGFs) deficiencies that lead to abnormal pancreatic endocrine development and
function with 3 specific aims.
1. Analyze pancreatic development and function to define critical developmental
periods and identify the adaptations imposed by decreased nutrient availability
in the IUGR fetus.
2. Determine the effects of nutrient and hormonal deficiencies on insulin
production and secretion in pancreatic endocrine cells in the IUGR fetus.
3. Test the ability to restore normal pancreatic development and function by in
vivo nutrient and hormonal supplementation during critical periods of
development in the IUGR fetus.
The proposed studies will be conducted in our ovine model of IUGR produced by
maternal exposure to a moderately hyperthermic environment during gestation.
These fetuses develop hypoglycemia and hypoaminoacidemia and secondary
deficiencies in insulin and GF concentrations in the latter third of gestation.
in vivo and in vitro studies will characterize pancreatic development and
function and determine mechanisms responsible for pancreatic abnormalities that
are direct consequences of fetal nutrient deprivation. The studies also will
provide insight into requirements for clinical interventions to ameliorate
pancreatic insufficiency in IUGR fetuses and neonates, hopefully to reduce
fetal and neonatal morbidity and mortality, and potentially to reduce the
incidence of adult onset diseases that have been associated with low birth
weight.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
ARTERIAL OXYGEN PARTIAL PRESSURE AND BLOOD OXYGENATION FROM PULSE OXIMETRY
-
批准号:7605059
-
项目类别:
-
资助金额:$0.49万
-
财政年份:2007
-
负责人:William W Hay
-
依托单位:
ARTERIAL OXYGEN PARTIAL PRESSURE AND BLOOD OXYGENATION FROM PULSE OXIMETRY
-
批准号:7202384
-
项目类别:
-
资助金额:$0.15万
-
财政年份:2005
-
负责人:William W Hay
-
依托单位:
Arterial Oxygen Partial Pressure and Blood Oxygenation
-
批准号:7041006
-
项目类别:
-
资助金额:$3.32万
-
财政年份:2004
-
负责人:William W Hay
-
依托单位:
Fetal pancreatic development & insulin secretion
-
批准号:6422088
-
项目类别:
-
资助金额:$56.35万
-
财政年份:2002
-
负责人:William W Hay
-
依托单位:
Fetal pancreatic development & insulin secretion
-
批准号:6882715
-
项目类别:
-
资助金额:$51.93万
-
财政年份:2002
-
负责人:William W Hay
-
依托单位:
Fetal pancreatic development & insulin secretion
-
批准号:7046964
-
项目类别:
-
资助金额:$52.23万
-
财政年份:2002
-
负责人:William W Hay
-
依托单位:
Fetal pancreatic development & insulin secretion
-
批准号:6612715
-
项目类别:
-
资助金额:$55.74万
-
财政年份:2002
-
负责人:William W Hay
-
依托单位:
FETAL GLUCOSE AND AMINO ACID DEPRIVATION
-
批准号:6332541
-
项目类别:
-
资助金额:$14.35万
-
财政年份:2000
-
负责人:William W Hay
-
依托单位:
FETAL GLUCOSE AND AMINO ACID DEPRIVATION
-
批准号:6296779
-
项目类别:
-
资助金额:$14.35万
-
财政年份:1999
-
负责人:William W Hay
-
依托单位:
FETAL GLUCOSE AND AMINO ACID DEPRIVATION
-
批准号:6108428
-
项目类别:
-
资助金额:$14.35万
-
财政年份:1999
-
负责人:William W Hay
-
依托单位:
FETAL GLUCOSE AND AMINO ACID DEPRIVATION
-
批准号:6272083
-
项目类别:
-
资助金额:$14.24万
-
财政年份:1998
-
负责人:William W Hay
-
依托单位:
USE OF NONINVASIVE OXIMETERS IN MONITORING CRITICALLY ILL CHILDREN
-
批准号:6114962
-
项目类别:
-
资助金额:$1.99万
-
财政年份:1998
-
负责人:William W Hay
-
依托单位:
Fetal Glucose and Amino Acid Deprivation
-
批准号:6721365
-
项目类别:
-
资助金额:$38.64万
-
财政年份:1997
-
负责人:William W Hay
-
依托单位:
USE OF NONINVASIVE OXIMETERS IN MONITORING CRITICALLY ILL CHILDREN
-
批准号:6276197
-
项目类别:
-
资助金额:$1.86万
-
财政年份:1997
-
负责人:William W Hay
-
依托单位:
USE OF NONINVASIVE OXIMETERS IN MONITORING CRITICALLY ILL CHILDREN
-
批准号:6246103
-
项目类别:
-
资助金额:$1.71万
-
财政年份:1997
-
负责人:William W Hay
-
依托单位:
FETAL GLUCOSE AND AMINO ACID DEPRIVATION
-
批准号:6177845
-
项目类别:
-
资助金额:$25.69万
-
财政年份:1997
-
负责人:William W Hay
-
依托单位:
Fetal Glucose and Amino Acid Deprivation
-
批准号:6624199
-
项目类别:
-
资助金额:$38.32万
-
财政年份:1997
-
负责人:William W Hay
-
依托单位:
Fetal Glucose and Amino Acid Deprivation
-
批准号:6472975
-
项目类别:
-
资助金额:$45.62万
-
财政年份:1997
-
负责人:William W Hay
-
依托单位:
FETAL GLUCOSE AND AMINO ACID DEPRIVATION
-
批准号:2395331
-
项目类别:
-
资助金额:$24.65万
-
财政年份:1997
-
负责人:William W Hay
-
依托单位:
Fetal Glucose and Amino Acid Deprivation
-
批准号:6873644
-
项目类别:
-
资助金额:$38.7万
-
财政年份:1997
-
负责人:William W Hay
-
依托单位:
海外基金