FETAL GLUCOSE AND AMINO ACID DEPRIVATION
胎儿血糖和氨基酸剥夺
基本信息
- 批准号:6296779
- 负责人:
- 金额:$ 14.35万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1999
- 资助国家:美国
- 起止时间:1999-07-01 至 2000-06-30
- 项目状态:已结题
- 来源:
- 关键词:acidosis aminoacid metabolism aminoacid transport dietary proteins disease /disorder model embryo /fetus fatty acid biosynthesis glucose metabolism hypoglycemia injection /infusion insulin sensitivity /resistance lactates model design /development mother /embryo /fetus nutrition nitrogen balance nutrition related tag pancreas hormone placental transfer pregnancy prenatal growth disorder protein biosynthesis protein degradation secretion sheep
项目摘要
Fetal growth restriction (FGR) from nutrient deprivation results in fetal
metabolic adaptations including decreased insulin secretion and insulin
sensitivity, and increased protein breakdown. These adaptations might
limit fetal metabolic capacity to respond successfully to attempts at
aggressive nutrient therapy. In this project, we will use our established
FGR model of fetal glucose and insulin deficiency (with normoaminacidemia)
from maternal hypoglycemia, and a new FGR model to be developed under
Specific Aim #1 of maternal low-protein diet plus/minus hypoaminoacidemia
(with normoglycemia), to test how well these FGR fetuses respond
metabolically to increased nutrient supply. We will test 4 hypotheses: 1.
rapid, high rates of glucose infusion into the FGR fetus will produce
excessive hypoxemia, acidosis, and lactate production; 2. rapid, high
rates of infusion of selected amino acids into the FGR fetus will produce
less than expected rates of their metabolism; 3. slow introduction of
glucose to the FGR fetus will normalize insulin secretion and insulin
sensitivity, allowing increased glucose and amino acid metabolism; 4. slow
introduction of amino acids to the FGR fetus will normalize insulin
secretion and insulin sensitivity, allowing increased glucose and amino
acid metabolism. Experiments will use our established methods of
substrate and hormone clamps and Fick principle and tracer measurements to
quantify fetal nutrient substrate entry, utilization, and oxidation rates.
These will be the first studies to determine how amino acid supply to the
fetus regulates fetal insulin secretion, and the first studies to define
how reintroduction of previously deficient nutrients to the FGR fetus
affects fetal metabolism, providing essential data to plan future clinical
trials of nutrient therapy of human FGR.
营养缺乏导致胎儿生长受限(FGR)
代谢适应,包括胰岛素分泌和胰岛素减少
敏感性,并增加蛋白质分解。 这些调整可能会
限制胎儿的代谢能力以成功应对尝试
积极的营养治疗。 在这个项目中,我们将使用我们已经建立的
胎儿葡萄糖和胰岛素缺乏的 FGR 模型(伴有正常氨基酸血症)
产妇低血糖,以及将在下开发的新 FGR 模型
母亲低蛋白饮食加/减低氨基酸血症的具体目标#1
(血糖正常),测试这些 FGR 胎儿的反应如何
代谢以增加营养供应。 我们将检验 4 个假设: 1.
快速、高速率的葡萄糖输注到 FGR 胎儿中会产生
过度低氧血症、酸中毒和乳酸产生; 2. 快速、高
将选定的氨基酸输注到 FGR 胎儿中的速率将产生
新陈代谢率低于预期; 3. 缓慢引入
FGR胎儿的葡萄糖将使胰岛素分泌和胰岛素正常化
敏感性,允许增加葡萄糖和氨基酸代谢; 4. 慢
将氨基酸引入 FGR 胎儿将使胰岛素正常化
分泌和胰岛素敏感性,允许增加葡萄糖和氨基
酸代谢。 实验将使用我们既定的方法
底物和激素夹以及菲克原理和示踪剂测量
量化胎儿营养底物的进入、利用率和氧化率。
这些将是第一个确定氨基酸供应方式的研究
胎儿调节胎儿胰岛素分泌,第一个研究定义
如何将先前缺乏的营养重新引入 FGR 胎儿
影响胎儿代谢,为规划未来的临床提供重要数据
人类 FGR 营养治疗试验。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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William W Hay其他文献
EFFECT OF INCREASING GLUCOSE CONCENTRATION ALONE ON FETAL GLUCOSE UTILIZATION
- DOI:
10.1203/00006450-198704010-01040 - 发表时间:
1987-04-01 - 期刊:
- 影响因子:3.100
- 作者:
Jane E Digiacomo;William W Hay;Frederick C Battaglia - 通讯作者:
Frederick C Battaglia
Achieving Positive Protein Balance in the Immediate Post-Operative Period in Neonates with Amino Acid Administration Plus Narcotic Analgesia
- DOI:
10.1203/00006450-199904020-01642 - 发表时间:
1999-04-01 - 期刊:
- 影响因子:3.100
- 作者:
Marianne S Anderson;Patti J Thureen;Karen A Baron;Kathryn D Bass;Diane L Melara;William W Hay - 通讯作者:
William W Hay
Ovine Placental and Fetal Arginine Metabolism at Normal and Elevated Maternal Plasma Arginine Concentrations † 1577
- DOI:
10.1203/00006450-199804001-01599 - 发表时间:
1998-04-01 - 期刊:
- 影响因子:3.100
- 作者:
Patti J Thureen;Adrian W Pike;Karen A Baron;Paul V Fennessey;William W Hay - 通讯作者:
William W Hay
185 COMPARISON OF UMBILICAL GLUCOSE UPTAKE AND FETAL GLUCOSE TURNOVER RATES
185 脐血葡萄糖摄取与胎儿葡萄糖周转率的比较
- DOI:
10.1203/00006450-197804001-00190 - 发表时间:
1978-04-01 - 期刊:
- 影响因子:3.100
- 作者:
William W Hay;John W Sparks;Barbara J Quissell;Frederick C Battaglia;Giacomo Meschia - 通讯作者:
Giacomo Meschia
The Acute Effect of Selective Hyperglycemia and Hyperinsulinemia upon Fetal Ovine Glucose Transporter Proteins
选择性高血糖和高胰岛素血症对胎儿绵羊葡萄糖转运蛋白的急性影响
- DOI:
10.1203/00006450-199904020-00301 - 发表时间:
1999-04-01 - 期刊:
- 影响因子:3.100
- 作者:
U G Das;M Anderson;R A Erhardt;William W Hay;S U Devaskar - 通讯作者:
S U Devaskar
William W Hay的其他文献
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{{ truncateString('William W Hay', 18)}}的其他基金
ARTERIAL OXYGEN PARTIAL PRESSURE AND BLOOD OXYGENATION FROM PULSE OXIMETRY
脉搏血氧饱和度的动脉血氧分压和血氧饱和度
- 批准号:
7605059 - 财政年份:2007
- 资助金额:
$ 14.35万 - 项目类别:
ARTERIAL OXYGEN PARTIAL PRESSURE AND BLOOD OXYGENATION FROM PULSE OXIMETRY
脉搏血氧饱和度的动脉血氧分压和血氧饱和度
- 批准号:
7202384 - 财政年份:2005
- 资助金额:
$ 14.35万 - 项目类别:
Arterial Oxygen Partial Pressure and Blood Oxygenation
动脉氧分压和血液氧合
- 批准号:
7041006 - 财政年份:2004
- 资助金额:
$ 14.35万 - 项目类别: