ARTERIAL OXYGEN PARTIAL PRESSURE AND BLOOD OXYGENATION FROM PULSE OXIMETRY

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Pulse oximetry has been used in newborn medicine to monitor oxygenation in preterm and term infants for several years. The Principal Investigator and his staff have conducted much of the clinical research validating two of these instruments. Because of the reliability of these instruments they have replaced transcutaneous PaO2 monitors and most blood sampling by direct arterial puncture techniques and have reduced routine indirect (via catheter) determinations of blood oxygen partial pressure. However, measurement of PaO2 serves to avoid selected PaO2 specific morbidities such as retinopathy of prematurity from too high a concentration of oxygen. The research proposed here would examine the use of advanced pulse oximetry to: better predict arterial PaO2, allow maintenance of SpO2 in discrete saturation ranges, detect true hypoxemia events during low perfusion conditions, and accurately measure SpO2 in high motion conditions.