Inhibition Errors in Schizophrenia: An fMRI/MEG Study

描述(由申请人提供)： 长期目标： 1.增进我对精神分裂症认知功能保留和受损的认识，以及它们与精神障碍的精神表现之间的关系。 2.学会使用高分辨率时空成像进行认知神经科学的研究，包括快速呈现、事件相关功能磁共振成像和脑磁图。 3.精通fMRI/MEG组合项目的设计、实施和数据分析。 具体目标： I.在健康受试者中，使用快速呈现、事件相关的fMRI和MEG来识别与a)完整抑制、b)抑制错误和c)错误处理相关的激活的时空模式。 Ii.在精神分裂症患者中，使用快速呈现、事件相关的功能磁共振成像和脑磁图来识别抑制异常和错误处理在神经激活的位置、时间和大小方面完好无损的阶段。

DESCRIPTION (provided by applicant): Long-term Goals: 1. To advance my knowledge of preserved versus impaired cognitive functions in schizophrenia, and how they relate to the psychiatric manifestations of the disorder. 2. To learn to conduct research in cognitive neuroscience using high resolution spatiotemporal imaging, including rapid presentation, event-related fMRI and MEG. 3. To become proficient in design, implementation and data analysis of combined fMRI/MEG projects. Specific Aims: I. In healthy subjects, to identify the spatiotemporal patterns of activation associated with a) intact inhibition, b) inhibition errors, and c) error processing using rapid-presentation, event-related fMRI and MEG. II. In schizophrenia, to identify the stages at which inhibition is abnormal and error processing is intact with regard to the location, timing, and magnitude of neural activation using rapid-presentation, event-related fMRI and MEG.